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Anti-CEACAM5 Antibody-PE (3C451)
还可以产品编号 TMAY-01606P
Anti-CEACAM5 Antibody-PE (3C451) 是一种 PE-conjugated Rabbit 抗体，靶向 CEACAM5。Anti-CEACAM5 Antibody-PE (3C451) 可用于 FCM。
Anti-CEACAM5 Antibody-PE (3C451)
Anti-CEACAM5 Antibody-PE (3C451)
还可以产品编号 TMAY-01606P
Anti-CEACAM5 Antibody-PE (3C451) 是一种 PE-conjugated Rabbit 抗体，靶向 CEACAM5。Anti-CEACAM5 Antibody-PE (3C451) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-CEACAM5 Antibody-PE (3C451) is a PE-conjugated Rabbit antibody targeting CEACAM5. Anti-CEACAM5 Antibody-PE (3C451) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 3C451 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of anti-Human CEACAM5 on HT29 cells. |
| 应用 | FCM |
| 推荐剂量 | 2 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human CEACAM5 / CD66e (rh CEACAM5 / CD66e; TMPY-01647; NP_004354.2; Met1-Ala685) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | CEACAM5, also known as CEA or CD66e, belongs to the large CEACAM subfamily of the immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with an MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domains and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC/FITC |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human CEACAM5 / CD66e protein (TMPY-01647) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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