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Anti-ICAM-1/CD54 Antibody-PE (7D308)
还可以产品编号 TMAY-03293P
Anti-ICAM-1/CD54 Antibody-PE (7D308) 是一种 PE-conjugated Rabbit 抗体，靶向 ICAM-1/CD54。Anti-ICAM-1/CD54 Antibody-PE (7D308) 可用于 FCM。
Anti-ICAM-1/CD54 Antibody-PE (7D308)
Anti-ICAM-1/CD54 Antibody-PE (7D308)
还可以产品编号 TMAY-03293P
Anti-ICAM-1/CD54 Antibody-PE (7D308) 是一种 PE-conjugated Rabbit 抗体，靶向 ICAM-1/CD54。Anti-ICAM-1/CD54 Antibody-PE (7D308) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-ICAM-1/CD54 Antibody-PE (7D308) is a PE-conjugated Rabbit antibody targeting ICAM-1/CD54. Anti-ICAM-1/CD54 Antibody-PE (7D308) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 7D308 |
| 交叉反应 | Mouse |
| 验证活性 | Analysis of ICAM1 (CD54) expression on spleen lymphocytes. Naive BALB/c splenocytes were treated with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 and stained with PE-conjugated anti-Mouse ICAM1 (CD54). The histogram were derived from the gated events based on light scattering characteristics of lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD54 / ICAM1 (rM CD54 / ICAM1; TMPY-01349; NP_034623.1; Met 1-Asn 485) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.1% sodium azide |
| 研究背景 | Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for some immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity. |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/FITC |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Mouse ICAM-1 protein (TMPY-01349) |
| 抗原种属 | Mouse |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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