Name: Gaboxadol hydrochloride
Brand: TargetMol
SKU: T7803
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 mg

¥ 291

待询

10 mg

¥ 417

待询

25 mg

¥ 777

待询

50 mg

¥ 987

待询

100 mg

¥ 1,587

待询

200 mg

¥ 2,380

待询

1 mL x 10 mM (in DMSO)

¥ 421

待询

产品介绍

生物活性

产品描述	Gaboxadol (hydrochloride) is a GABAA receptor agonist.
体内活性	Gaboxadol produced ≥80 % gaboxadol-lever responding and did not alter rates. No other drug produced, on average, ≥80 % drug-lever responding up to doses that decreased rates, although 1.78 mg/kg midazolam produced 32 % gaboxadol-lever responding. Ethanol and pregnanolone did not enhance the effects of gaboxadol. Rats discriminating midazolam, pregnanolone, or ethanol from vehicle responded predominantly on the vehicle lever after receiving gaboxadol[1].
动物实验	Eight rats discriminated 5.6 mg/kg gaboxadol from vehicle while responding under a fixed - ratio 10 schedule for food.?Modulators acting at GABAA receptors containing α4-δ subunits (pregnanolone, ethanol, and flumazenil) and receptors that do not contain those subunits (midazolam) were studied alone ;?pregnanolone and ethanol were also combined with gaboxadol.?In addition, gaboxadol was studied in separate groups discriminating 0.32 mg/kg midazolam, 3.2 mg/kg pregnanolone, or 0.75 g/kg ethanol from vehicle[1].
别名	加波沙朵盐酸盐, 加波沙朵, THIP (hydrochloride), Lu 02-030 (hydrochloride), GAB氧杂DOL盐酸盐, Gaboxadol (hydrochloride)

化学信息

分子量	176.601
分子式	C₆H₉ClN₂O₂
CAS No.	85118-33-8
Smiles	Cl.Oc1noc2CNCCc12
密度	no data available
颜色	White
物理性状	solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 75 mg/mL (424.69 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6625 mL	28.3124 mL	56.6248 mL	283.1241 mL
5 mM	1.1325 mL	5.6625 mL	11.3250 mL	56.6248 mL
10 mM	0.5662 mL	2.8312 mL	5.6625 mL	28.3124 mL
20 mM	0.2831 mL	1.4156 mL	2.8312 mL	14.1562 mL
50 mM	0.1132 mL	0.5662 mL	1.1325 mL	5.6625 mL
100 mM	0.0566 mL	0.2831 mL	0.5662 mL	2.8312 mL

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH₂O，那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300/ PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

Gaboxadol hydrochloride

Gaboxadol hydrochloride

产品介绍

计算器

体内实验配液计算器

剂量转换

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