规格

价格

库存

数量

5 mg

¥ 291

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10 mg

¥ 417

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25 mg

¥ 777

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50 mg

¥ 987

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100 mg

¥ 1,587

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200 mg

¥ 2,380

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1 mL x 10 mM (in DMSO)

¥ 421

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生物活性

产品描述	Gaboxadol (hydrochloride) is a GABAA receptor agonist.
体内活性	Gaboxadol produced ≥80 % gaboxadol-lever responding and did not alter rates. No other drug produced, on average, ≥80 % drug-lever responding up to doses that decreased rates, although 1.78 mg/kg midazolam produced 32 % gaboxadol-lever responding. Ethanol and pregnanolone did not enhance the effects of gaboxadol. Rats discriminating midazolam, pregnanolone, or ethanol from vehicle responded predominantly on the vehicle lever after receiving gaboxadol[1].
动物实验	Eight rats discriminated 5.6 mg/kg gaboxadol from vehicle while responding under a fixed - ratio 10 schedule for food.?Modulators acting at GABAA receptors containing α4-δ subunits (pregnanolone, ethanol, and flumazenil) and receptors that do not contain those subunits (midazolam) were studied alone ;?pregnanolone and ethanol were also combined with gaboxadol.?In addition, gaboxadol was studied in separate groups discriminating 0.32 mg/kg midazolam, 3.2 mg/kg pregnanolone, or 0.75 g/kg ethanol from vehicle[1].
别名	加波沙朵盐酸盐, 加波沙朵, THIP (hydrochloride), Lu 02-030 (hydrochloride), GAB氧杂DOL盐酸盐, Gaboxadol (hydrochloride)

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 75 mg/mL (424.69 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1.67 mg/mL (9.46 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO