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Anti-CD146/MCAM Antibody (5R295)
还可以产品编号 TMAY-03463
别名 MUC18, melanoma cell adhesion molecule, CD146
Anti-CD146/MCAM Antibody (5R295) 是一种 Rabbit 抗体，靶向 CD146/MCAM。Anti-CD146/MCAM Antibody (5R295) 可用于 IHC-P。
Anti-CD146/MCAM Antibody (5R295)
Anti-CD146/MCAM Antibody (5R295)
还可以产品编号 TMAY-03463 别名 MUC18, melanoma cell adhesion molecule, CD146
Anti-CD146/MCAM Antibody (5R295) 是一种 Rabbit 抗体，靶向 CD146/MCAM。Anti-CD146/MCAM Antibody (5R295) 可用于 IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,294 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD146/MCAM Antibody (5R295) is a Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (5R295) can be used in IHC-P. |
| 别名 | MUC18, melanoma cell adhesion molecule, CD146 |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5R295 |
| 交叉反应 | Mouse |
| 验证活性 | Immunochemical staining of mouse MCAM in mouse liver with rabbit monoclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD146 / MCAM (rM CD146 / MCAM; TMPY-02502; Q8R2Y2-1; Met1-Val563). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse CD146 / MCAM Protein (TMPY-02502) |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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