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EpCAM/TROP1 Protein, Human, Recombinant (His)

产品编号 TMPY-01300

别名: TROP-1, ESA, EGP40, HNPCC8, EGP314, M4S1, epithelial cell adhesion molecule, MK-1, MIC18, DIAR5, EGP-2, KS1/4, TACSTD1, TROP1, KSA

EpCAM/TROP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.84 kDa and the accession number is P16422.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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EpCAM/TROP1 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 2,410		现货
200 μg	￥ 4,270		5日内发货

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参考文献

生物活性	Measured by the ability of the immobilized protein to support the adhesion of NIH-3T3 mouse embryonic fibroblast cells. When cells are added to EpCAM-His coated plates (1.25μg/mL, 100μL/well), approximately >40% will adhere specifically after 30 minutes at 37℃.
产品描述	EpCAM/TROP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.84 kDa and the accession number is P16422.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P16422
别名	TROP-1, ESA, EGP40, HNPCC8, EGP314, M4S1, epithelial cell adhesion molecule, MK-1, MIC18, DIAR5, EGP-2, KS1/4, TACSTD1, TROP1, KSA
蛋白构建	The extracellular domain (Met1-Lys265) of Human EpCAM (NP_002345.1) was fused with a polyhistidine tag at the C-terminus.
蛋白纯度	> 96 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量	28.84 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10. 2. Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5. 3. Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6. 4. Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.

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Keywords

EpCAM/TROP1 Protein, Human, Recombinant (His) HNPCC-8 MIC-18 HNPCC 8 MK1 TROP-1 DIAR-5 ESA EGP40 HNPCC8 EGP-314 EGP314 M4S1 epithelial cell adhesion molecule EGP 40 EGP-40 MK-1 MIC18 MK 1 DIAR5 EGP 314 TROP 1 EGP-2 TACSTD-1 DIAR 5 TACSTD 1 EGP2 KS1/4 TACSTD1 TROP1 MIC 18 KSA EGP 2 recombinant recombinant-proteins proteins protein

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