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CD146/MCAM Protein, Human, Recombinant (hFc)

产品编号 TMPY-00879

别名: MUC18, melanoma cell adhesion molecule, CD146

CD146/MCAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 86.4 kDa and the accession number is A0A024R3I5.

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CD146/MCAM Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
50 μg	￥ 2,530		5日内发货
500 μg	￥ 16,500		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	CD146/MCAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 86.4 kDa and the accession number is A0A024R3I5.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	A0A024R3I5
别名	MUC18, melanoma cell adhesion molecule, CD146
蛋白构建	The extracellular domain (Met 1-Gly 559) of Human CD146 precursor (NP_006491.2) was expressed with the C-terminal fused Fc region of Human IgG1.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	86.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas.

参考文献

1. Mills L,et al.(2002) Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 62(17): 5106-14. 2. Taira E,et al.(2004) Characterization of Gicerin/MUC18/CD146 in the rat nervous system. J Cell Physiol. 198(3): 377-87. 3. Fritzsche FR,et al.(2008) CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 40(5): 457-64. 4. Bidlingmaier S,et al.(2009) Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 69(4): 1570-7. 5. Boneberg EM,et al.(2009) Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process. Microvasc Res. 78(3): 325-31.

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Keywords

CD146/MCAM Protein, Human, Recombinant (hFc) MUC18 melanoma cell adhesion molecule CD-146 MUC-18 CD146 MUC 18 CD 146 recombinant recombinant-proteins proteins protein

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