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Anti-FURIN Antibody (5P939)
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产品编号 TMAC-01574
别名 PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme
Anti-FURIN Antibody (5P939) 是一种 Rabbit 抗体，靶向 FURIN。Anti-FURIN Antibody (5P939) 可用于 WB,IHC,ICC。
Anti-FURIN Antibody (5P939)
Anti-FURIN Antibody (5P939)
还可以产品编号 TMAC-01574 别名 PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme
Anti-FURIN Antibody (5P939) 是一种 Rabbit 抗体，靶向 FURIN。Anti-FURIN Antibody (5P939) 可用于 WB,IHC,ICC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,480 | 5日内发货 |
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产品介绍
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抗原信息
化学信息
| 产品描述 | Anti-FURIN Antibody (5P939) is a Rabbit antibody targeting FURIN. Anti-FURIN Antibody (5P939) can be used in WB,IHC,ICC. |
| 别名 | PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of Furin on different cell lysates using anti-Furin antibody at 1/500 dilution. Positive control: Lane 1: HepG2, Lane 2: Hela, Lane 3: Hela, Lane 4: MCF-7. 2. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Furin antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-Furin antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-Furin antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Furin antibody. Counter stained with hematoxylin. |
| 应用 | |
| 推荐剂量 | WB: 1:500-1000; IHC: 1:50; ICC: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Furin (FUR, PACE, PCSK3, SPC1, Kex2p) is a calcium-dependent serine endoprotease that belongs to the subtilisin-like proprotein convertase family. The members of this family process latent precursor proteins into their biologically active products. Furin cleaves at paired basic amino acid processing sites within proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. Furin can directly cleave proMMP-2 within the trans-Golgi network leading to an inactive form of matrix metalloproteinase-2 (MMP-2). Furin is synthesized as an inactive zymogen that may minimize the occurrence of premature enzymatic activity that would lead to alternative protein activation or degradation. The inhibitory mechanism is based on the presence of an inactivating prosegment at the NH2 terminal of the Furin. After initial autocatalytic cleavage, the prosegment remains tightly associated until it reaches the trans-Golgi network where the dissociation of the prosegment and activation of furin occurs. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: human Furin aa 200-400 |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Theoretical: 87 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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