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Anti-CADM3 Antibody (4Z747)

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产品编号 TMAY-03312

Anti-CADM3 Antibody (4Z747) 是一种 Rabbit 抗体,靶向 CADM3。Anti-CADM3 Antibody (4Z747) 可用于 ELISA。

Anti-CADM3 Antibody (4Z747)

Anti-CADM3 Antibody (4Z747)

Rating icon 还可以
产品编号 TMAY-03312

Anti-CADM3 Antibody (4Z747) 是一种 Rabbit 抗体,靶向 CADM3。Anti-CADM3 Antibody (4Z747) 可用于 ELISA。

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产品介绍

生物活性
产品描述
Anti-CADM3 Antibody (4Z747) is a Rabbit antibody targeting CADM3. Anti-CADM3 Antibody (4Z747) can be used in ELISA.
Ig Type
Monoclonal Rabbit IgG
克隆号
4Z747
交叉反应
Mouse
应用
ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CADM3 / NECL1 / IGSF4B (rM CADM3 / NECL1 / IGSF4B; TMPY-01607; NP_444429.1; Met 1-His 328).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain that interacts either with other CAMs of the same kind (homophilic binding) or with other CAMs or the extracellular matrix (heterophilic binding). Cell adhesion molecule 3, also known as Immunoglobulin superfamily member 4B, CADM3, and NECL1, is a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule which has Ca(2+)-independent homo- or heterophilic cell-cell adhesion activity and plays an important role in the formation of synapses, axon bundles and myelinated axons. Isoform 1 of CADM3 is expressed mainly in adult and fetal brain. Isoform 2 of CADM3 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. CADM3 is involved in the cell-cell adhesion. It has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. The interaction with EPB41L1 may regulate structure or function of cell-cell junctions. CADM3 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Mouse CADM3 / NECL1 / IGSF4B Protein (TMPY-01607)
抗原种属
Mouse
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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