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CEACAM1 Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-00205

别名: MHVR, MHVR1, Cea-7, mmCGM1a, Cea-1, Cc1, carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein), Cea7, C-CAM, Hv-2, mCEA1, Hv2, Cea1, CD66a, mmCGM1, Mhv-1, Bgp, mmCGM2, Bgp1, bb-1

CEACAM1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.3 kDa and the accession number is Q925P3.

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CEACAM1 Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
200 μg	￥ 5,750		5日内发货
1 mg	￥ 24,900		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	CEACAM1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.3 kDa and the accession number is Q925P3.

种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q925P3
别名	MHVR, MHVR1, Cea-7, mmCGM1a, Cea-1, Cc1, carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein), Cea7, C-CAM, Hv-2, mCEA1, Hv2, Cea1, CD66a, mmCGM1, Mhv-1, Bgp, mmCGM2, Bgp1, bb-1
蛋白构建	The Mouse Ceacam1 (NP_001034274.1) (Met1-Gly428) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 85 % as determined by SDS-PAGE
分子量	70.3 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

1. Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46. 2. Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82. 3. Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.

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Keywords

CEACAM1 Protein, Mouse, Recombinant (hFc) MHVR MHVR1 biliary glycoprotein MHVR-1 Cea-7 mmCGM1a Cea-1 Cc1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) MHVR 1 Cea7 C-CAM Hv-2 mCEA1 Hv2 Cea1 CD66a mmCGM1 Mhv-1 Bgp mmCGM2 Bgp1 bb-1 recombinant recombinant-proteins proteins protein

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