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Anti-CEACAM1 Antibody (7W928)
还可以产品编号 TMAH-00259
别名 CEACAM‑1, CD66a, carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein), BGPI, BGP1, BGP
Anti-CEACAM1 Antibody (7W928) 是一种抗体，靶向 CEACAM1。Anti-CEACAM1 Antibody (7W928) 可用于 ELISA。
Anti-CEACAM1 Antibody (7W928)
Anti-CEACAM1 Antibody (7W928)
还可以产品编号 TMAH-00259 别名 CEACAM‑1, CD66a, carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein), BGPI, BGP1, BGP
Anti-CEACAM1 Antibody (7W928) 是一种抗体，靶向 CEACAM1。Anti-CEACAM1 Antibody (7W928) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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偶联与修饰
抗原信息
| 产品描述 | Anti-CEACAM1 Antibody (7W928) is an antibody targeting CEACAM1. Anti-CEACAM1 Antibody (7W928) can be used in ELISA. |
| 别名 | CEACAM‑1, CD66a, carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein), BGPI, BGP1, BGP |
| Ig Type | hIgG1 |
| 克隆号 | 7W928 |
| 交叉反应 | Human |
| 验证活性 | The Binding Activity of Human CEACAM1 with Anti-CEACAM1 recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM1 at 2 μg/mL can bind Anti-CEACAM1 recombinant antibody(TMAH-00259). The EC50 is 3.432 - 6.079 ng/mL. |
| 应用 | ELISA |
| 推荐剂量 | ELISA:1:5000-1:50000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Lateral cell membrane. Apical cell membrane. Basal cell membrane. Cell junction. Cell junction, adherens junction.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Cell membrane; Single-pass type I membrane protein.; [Isoform 6]: Cell membrane; Single-pass type I membrane protein.; [Isoform 7]: Cell membrane; Single-pass type I membrane protein.; [Isoform 8]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane. Lateral cell membrane. Apical cell membrane. Basal cell membrane. Cell junction. Cell junction, adherens junction.; Cell projection, microvillus membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils. Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70. Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2. Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation. Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R. Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling. Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways. Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production. Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway. Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex. Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA. Mediates bile acid transport activity in a phosphorylation dependent manner. Negatively regulates osteoclastogenesis. Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human CEACAM Protein |
| 抗原种属 | Human |
| 基因ID | 634 |
| Uniprot ID | |
| 研究领域 | Cancer, Tags & Cell Markers, Immunology, Microbiology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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