S-MGB-234

Name: S-MGB-234
Brand: TargetMol
SKU: T39397
Rating: 4.5 (1 reviews)

还可以

产品编号 T39397Cas号 1970223-53-0

S-MGB-234 is a minor groove binder utilized for the treatment of Animal African Trypanosomiasis (AAT). It exhibits exceptional in vitro efficacy against the primary causative agents of AAT, namely Trypanosoma congolense and Trypanosoma vivax. Moreover, S-MGB-234 does not demonstrate cross-resistance with existing diamidine drugs and is not internalized through the transporters employed by diamidines.

S-MGB-234

还可以

产品编号 T39397Cas号 1970223-53-0

规格	价格	库存	数量
25 mg	¥ 10,600	待询

大包装 & 定制

加入购物车

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

S-MGB-234 相关产品

联系我们获取更多批次信息

资源下载

产品操作手册

产品介绍

生物活性

产品描述	S-MGB-234 is a minor groove binder utilized for the treatment of Animal African Trypanosomiasis (AAT). It exhibits exceptional in vitro efficacy against the primary causative agents of AAT, namely Trypanosoma congolense and Trypanosoma vivax. Moreover, S-MGB-234 does not demonstrate cross-resistance with existing diamidine drugs and is not internalized through the transporters employed by diamidines.
体外活性	S-MGB-234 (compound 7) (69 hours) shows nontoxic to L6 cells with an EC 50 of 20.39 μM[1].
体内活性	S-MGB-234 (compound 7) provides total cure and no relapses in mice (cured/infected, 4/4), when treated with 2 applications of 50 mg/kg i.p.. Partial cure (1/4) is seen in mice treated with four daily applications of 10 mg/kg i.p., whilst only two applications of S-MGB-234 (compound 7) at 10 mg/kg i.p. gives no cure but prolongs survival relative to the untreated control[1].