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CD166/ALCAM Protein, Human, Recombinant (His)

产品编号 TMPY-01578

别名: activated leukocyte cell adhesion molecule, CD166, MEMD

CD166/ALCAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is Q13740-1.

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CD166/ALCAM Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 2,520		现货
200 μg	￥ 4,470		5日内发货

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生物活性	Immobilized human ALCAM-His at 10 μg/ml (100 μl/well) can bind mouse CD6-Fc , The EC50 of mouse CD6-Fc is 0.1-0.22 μg/ml.
产品描述	CD166/ALCAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is Q13740-1.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q13740-1
别名	activated leukocyte cell adhesion molecule, CD166, MEMD
蛋白构建	The extracellular domain (Met1-Ala526) of Human ALCAM (NP_001618.2) was expressed with the C-terminal polyhistidine tag.
蛋白纯度	≥ 98 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	57.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target.

参考文献

1. Swart GW. (2002) Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell migration. Eur J Cell Biol. 81(6): 313-21. 2. Fujiwara H,et al.(2003) Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166). J Clin Endocrinol Metab. 88(7): 3437-43. 3. Jezierska A,et al.(2006) ALCAM/CD166 protects breast cancer cells against apoptosis and autophagy. Med Sci Monit. 12(8): BR263-73. 4. Kahlert C,et al.(2009) Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse. Br J Cancer. 101(3): 457-64.

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Keywords

CD166/ALCAM Protein, Human, Recombinant (His) activated leukocyte cell adhesion molecule CD-166 CD 166 CD166 MEMD recombinant recombinant-proteins proteins protein

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