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Anti-JAML Antibody (9U237)
还可以产品编号 TMAY-00298
Anti-JAML Antibody (9U237) 是一种 Mouse 抗体，靶向 JAML。Anti-JAML Antibody (9U237) 可用于 ELISA(Cap)。
Anti-JAML Antibody (9U237)
Anti-JAML Antibody (9U237)
还可以产品编号 TMAY-00298
Anti-JAML Antibody (9U237) 是一种 Mouse 抗体，靶向 JAML。Anti-JAML Antibody (9U237) 可用于 ELISA(Cap)。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-JAML Antibody (9U237) is a Mouse antibody targeting JAML. Anti-JAML Antibody (9U237) can be used in ELISA(Cap). |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 9U237 |
| 交叉反应 | Human |
| 应用 | ELISA(Cap) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAML / AMICA1 (rh JAML / AMICA1; TMPY-01164; NP_001091996.1; Met1-Leu275). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. It contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail involved in activation signaling. Monocytic JAML/AMICA1 plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. The Expression of JAML/AMICA1 is restricted to the hematopoietic tissues with the exception of liver. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML/AMICA1 also enhances myeloid leukemia cell adhesion to endothelial cells. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human JAML / AMICA1 Protein (TMPY-01164) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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