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IBSP Protein, Mouse, Recombinant (His)

IBSP Protein, Mouse, Recombinant (His)

产品编号 TMPJ-00445
别名: BNSP, IBSP, Integrin binding sialoprotein, Cell binding sialoprotein, SP II, Bone sialoprotein, BSPII, Bone sialoprotein 2, BSP2, BSP

Bone sialoprotein 2(IBSP) is a monomeric non‑collagenous member of the SIBLING family of extracellular matrix proteins. It is principally associated with the early stages of bone mineralization. Mouse IBSP is synthesized as a 324 amino acid (aa) precursor that contains a 16 aa signal sequence and a 308 aa mature region. The mature segment is divided into a basic N‑terminus (aa 17 ‑ 62), a central region (aa 63 ‑ 233), and an acidic C‑terminus (aa 234 ‑ 317). IBSP is highly glycosylated, sulfated and phosphorylated. Phosphorylation promotes HAp nucleation, while carbohydrate may regulate cell adhesion. IBSP binds tightly to hydroxyapatite, appears to form an integral part of the mineralized matrix. It is probably important to cell-matrix interaction and promotes Arg-Gly-Asp-dependent cell attachment.

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IBSP Protein, Mouse, Recombinant (His)
规格 价格/CNY 货期 数量
10 μg ¥ 580 5日内发货
50 μg ¥ 1,770 5日内发货
500 μg ¥ 7,110 5日内发货
1 mg ¥ 9,890 5日内发货
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产品目录号及名称: IBSP Protein, Mouse, Recombinant (His) (TMPJ-00445)
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产品描述 Bone sialoprotein 2(IBSP) is a monomeric non‑collagenous member of the SIBLING family of extracellular matrix proteins. It is principally associated with the early stages of bone mineralization. Mouse IBSP is synthesized as a 324 amino acid (aa) precursor that contains a 16 aa signal sequence and a 308 aa mature region. The mature segment is divided into a basic N‑terminus (aa 17 ‑ 62), a central region (aa 63 ‑ 233), and an acidic C‑terminus (aa 234 ‑ 317). IBSP is highly glycosylated, sulfated and phosphorylated. Phosphorylation promotes HAp nucleation, while carbohydrate may regulate cell adhesion. IBSP binds tightly to hydroxyapatite, appears to form an integral part of the mineralized matrix. It is probably important to cell-matrix interaction and promotes Arg-Gly-Asp-dependent cell attachment.
种属 Mouse
表达系统 HEK293 Cells
标签 C-6xHis
蛋白编号 AAA21726.1
别名 BNSP, IBSP, Integrin binding sialoprotein, Cell binding sialoprotein, SP II, Bone sialoprotein, BSPII, Bone sialoprotein 2, BSP2, BSP
氨基酸序列 Phe17-Gln324
蛋白构建 Phe17-Gln324
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 71 KDa (reducing condition)
内毒素 < 1 EU/μg by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Bone sialoprotein 2(IBSP) is a monomeric non‑collagenous member of the SIBLING family of extracellular matrix proteins. It is principally associated with the early stages of bone mineralization. Mouse IBSP is synthesized as a 324 amino acid (aa) precursor that contains a 16 aa signal sequence and a 308 aa mature region. The mature segment is divided into a basic N‑terminus (aa 17 ‑ 62), a central region (aa 63 ‑ 233), and an acidic C‑terminus (aa 234 ‑ 317). IBSP is highly glycosylated, sulfated and phosphorylated. Phosphorylation promotes HAp nucleation, while carbohydrate may regulate cell adhesion. IBSP binds tightly to hydroxyapatite, appears to form an integral part of the mineralized matrix. It is probably important to cell-matrix interaction and promotes Arg-Gly-Asp-dependent cell attachment.

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Keywords

IBSP Protein, Mouse, Recombinant (His) BNSP BSP-2 IBSP Integrin binding sialoprotein Cell binding sialoprotein SP II Bone sialoprotein BSPII Bone sialoprotein 2 BSP2 BSP 2 BSP recombinant recombinant-proteins proteins protein

 

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