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Anti-CD146/MCAM Antibody (1I919)
还可以产品编号 TMAY-00291
Anti-CD146/MCAM Antibody (1I919) 是一种 Mouse 抗体，靶向 CD146/MCAM。Anti-CD146/MCAM Antibody (1I919) 可用于 ELISA。
Anti-CD146/MCAM Antibody (1I919)
Anti-CD146/MCAM Antibody (1I919)
还可以产品编号 TMAY-00291
Anti-CD146/MCAM Antibody (1I919) 是一种 Mouse 抗体，靶向 CD146/MCAM。Anti-CD146/MCAM Antibody (1I919) 可用于 ELISA。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-CD146/MCAM Antibody (1I919) is a Mouse antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (1I919) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 1I919 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD146 / MCAM extracellular domain (rh CD146; TMPY-01034; NP_006491.2; Met 1-Gly 559). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CD146 protein (TMPY-01034) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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