Anti-CD50 Antibody (5P32)

Name: Anti-CD50 Antibody (5P32)
Brand: TargetMol
SKU: TMAY-00628
Rating: 4.5 (1 reviews)

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产品编号 TMAY-00628

别名 intercellular adhesion molecule 3, ICAM-R, ICAM-3, CDW50, CD50

Anti-CD50 Antibody (5P32) 是一种 Mouse 抗体，靶向 CD50。Anti-CD50 Antibody (5P32) 可用于 ELISA(Cap),FCM。

Anti-CD50 Antibody (5P32)

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产品编号 TMAY-00628 别名 intercellular adhesion molecule 3, ICAM-R, ICAM-3, CDW50, CD50

Anti-CD50 Antibody (5P32) 是一种 Mouse 抗体，靶向 CD50。Anti-CD50 Antibody (5P32) 可用于 ELISA(Cap),FCM。

规格	价格	库存	数量
20 μL	¥ 585	5日内发货
100 μL	¥ 1,679	5日内发货

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生物活性

产品描述	Anti-CD50 Antibody (5P32) is a Mouse antibody targeting CD50. Anti-CD50 Antibody (5P32) can be used in ELISA(Cap),FCM.
别名	intercellular adhesion molecule 3, ICAM-R, ICAM-3, CDW50, CD50
Ig Type	Mouse IgG2a
克隆号	5P32
交叉反应	Human
验证活性	Flow cytometric analysis of human ICAM3(CD50) expression on human peripheral blood lymphocytes. Cells were stained with purified anti-Human ICAM3(CD50), then a FITC-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of viable lymphocytes.
应用	ELISA(Cap) FCM
推荐剂量	FCM: 1:25-1:100; ELISA(Cap): 1:250-1:2000
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD50 / ICAM-3 (rh CD50 / ICAM-3; TMPY-01430; CAA49369.1; Met1-His485). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	The protein ICAM-3, also known as CD50, is a member of the intercellular adhesion molecule (ICAM) family consisting of three members. It is a DC-SIGN ligand that is constitutively expressed on resting leukocytes and is thus an important molecule for the first immune response. ICAM-3 comprises five immunoglobulin-like domains and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule but also as a potent signaling molecule. ICAM-3 binds to LFA-1 on antigen-presenting cells (APC) stabilizing the T cell-APC interaction, facilitating signaling through the CD3/TCR complex. However, recent evidence using cultured and transformed T cells suggests ICAM-3 may also function in signaling. It has been reported that the CD50 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes. Also, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells. ICAM-3 is associated with an increase in cellular radio-resistance and cancer cell proliferation. It could be considered as a candidate for anti-cancer drug development and as a cancer diagnostic marker.

偶联与修饰

偶联	Unconjugated
其他可选修饰符	APC/FITC/PE
可提供抗体种类	4

抗原信息

免疫原	Recombinant Protein: Human CD50 / ICAM-3 protein (TMPY-01430)
抗原种属	Human

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.