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JAML Protein, Mouse, Recombinant (hFc)

JAML Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-00224
别名: AMICA, Gm638, adhesion molecule, interacts with CXADR antigen 1, Crea7

JAML Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.5 kDa and the accession number is Q80UL9.

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JAML Protein, Mouse, Recombinant (hFc)
规格 价格/CNY 货期 数量
100 μg ¥ 3,820 5日内发货
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产品目录号及名称: JAML Protein, Mouse, Recombinant (hFc) (TMPY-00224)
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生物活性 Testing in progress
产品描述 JAML Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.5 kDa and the accession number is Q80UL9.
种属 Mouse
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 Q80UL9
别名 AMICA, Gm638, adhesion molecule, interacts with CXADR antigen 1, Crea7
蛋白构建 The Mouse (NP_001005421.3) (Met1-Leu281) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度 > 95 % as determined by SDS-PAGE
分子量 56.5 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. It contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail involved in activation signaling. Monocytic JAML/AMICA1 plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. The Expression of JAML/AMICA1 is restricted to the hematopoietic tissues with the exception of liver. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML/AMICA1 also enhances myeloid leukemia cell adhesion to endothelial cells.

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Keywords

JAML Protein, Mouse, Recombinant (hFc) AMICA Gm638 adhesion molecule, interacts with CXADR antigen 1 Crea7 recombinant recombinant-proteins proteins protein

 

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