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Anti-CD50 Antibody (9H972)
还可以产品编号 TMAY-00627
Anti-CD50 Antibody (9H972) 是一种 Mouse 抗体，靶向 CD50。Anti-CD50 Antibody (9H972) 可用于 IHC-P。
Anti-CD50 Antibody (9H972)
Anti-CD50 Antibody (9H972)
还可以产品编号 TMAY-00627
Anti-CD50 Antibody (9H972) 是一种 Mouse 抗体，靶向 CD50。Anti-CD50 Antibody (9H972) 可用于 IHC-P。
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抗原信息
| 产品描述 | Anti-CD50 Antibody (9H972) is a Mouse antibody targeting CD50. Anti-CD50 Antibody (9H972) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 9H972 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human ICAM3 in human tonsil with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human ICAM3 in human spleen with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human ICAM3 in human appendix with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD50 / ICAM-3 (rh CD50 / ICAM-3; TMPY-01430; CAA49369.1; Met1-His485). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The protein ICAM-3, also known as CD50, is a member of the intercellular adhesion molecule (ICAM) family consisting of three members. It is a DC-SIGN ligand that is constitutively expressed on resting leukocytes and is thus an important molecule for the first immune response. ICAM-3 comprises five immunoglobulin-like domains and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule but also as a potent signaling molecule. ICAM-3 binds to LFA-1 on antigen-presenting cells (APC) stabilizing the T cell-APC interaction, facilitating signaling through the CD3/TCR complex. However, recent evidence using cultured and transformed T cells suggests ICAM-3 may also function in signaling. It has been reported that the CD50 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes. Also, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells. ICAM-3 is associated with an increase in cellular radio-resistance and cancer cell proliferation. It could be considered as a candidate for anti-cancer drug development and as a cancer diagnostic marker. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CD50 / ICAM-3 protein (TMPY-01430) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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