Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZIM,一种从4-Aminoantipyrine衍生的降冰片烯,有效诱导DNA损伤,造成基因组及染色体损害,进而引发细胞死亡和激活吞噬。其化疗潜力适用于癌症研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 248 | 现货 | ||
5 mg | ¥ 547 | 现货 | ||
10 mg | ¥ 878 | 现货 | ||
25 mg | ¥ 1,780 | 现货 | ||
50 mg | ¥ 2,930 | 现货 | ||
100 mg | ¥ 4,350 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 773 | 现货 |
产品描述 | ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation. Its properties highlight its potential as a chemotherapeutic agent in cancer research. |
体内活性 |
ZIM (i.p., 12, 24, and 48 mg/kg) effectively reduces the chromosomal micronucleus frequency at all doses in adult male Swiss mice, with a chemical preventive effect observed at 24 and 72 hours, and the range of percentage decrease in damage is between 38.36% and 83.26%.[1] ZIM (i.p., 12, 24, and 48 mg/kg) lowers the frequency of liver cell and kidney cell death induced by cisplatin-CIS and doxorubicin-DOX. At concentrations of 12, 24, and 48 mg/kg, the percentage decrease in liver damage in the CIS group is 79.27%, 75.20%, and 52.84%, respectively, while in the DOX group, it is 62.06%, 59.44%, and 77.80%. The percentage decrease in kidney damage in the CIS group is 45.29%, 36.09%, and 41.61%, respectively, and in the DOX group, it is 28.00%, 21.41%, and 30.82%.[1] |
分子量 | 349.38 |
分子式 | C20H19N3O3 |
CAS No. | 301298-87-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (128.8 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8622 mL | 14.3111 mL | 28.6221 mL | 71.5553 mL |
5 mM | 0.5724 mL | 2.8622 mL | 5.7244 mL | 14.3111 mL | |
10 mM | 0.2862 mL | 1.4311 mL | 2.8622 mL | 7.1555 mL | |
20 mM | 0.1431 mL | 0.7156 mL | 1.4311 mL | 3.5778 mL | |
50 mM | 0.0572 mL | 0.2862 mL | 0.5724 mL | 1.4311 mL | |
100 mM | 0.0286 mL | 0.1431 mL | 0.2862 mL | 0.7156 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ZIM 301298-87-3 Inhibitor inhibitor inhibit