store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) 是一种铜绿假单胞菌为应对细胞密度增加而产生的一种法定人数感应信号分子。 它增加了铜绿假单胞菌中lasB 基因的表达,增加代谢物焦蓝蛋白和凝集素PA-IL 的分泌,以及增加铜绿假单胞菌种群的生物膜生产。当使用浓度为40 μM 时,它还会降低铜绿假单胞菌生长介质中的铁含量,并在硫酸铁溶液中充当一种铁螯合剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 540 | 现货 | ||
10 mg | ¥ 660 | 现货 | ||
25 mg | ¥ 1,130 | 现货 | ||
50 mg | ¥ 1,710 | 现货 | ||
100 mg | ¥ 2,630 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 394 | 现货 |
产品描述 | 2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) is a quorum-sensing signalling molecule produced by Pseudomonas aeruginosa in response to increased cell density. It increases the expression of the lasB gene in P. aeruginosa, the secretion of the metabolites pyocyanin and the lectin PA-IL, as well as increasing biofilm production in P. aeruginosa populations. It also reduces the iron content of the P. aeruginosa growth medium when used at a concentration of 40 μM and acts as an iron chelator in iron sulphate solutions. |
体外活性 |
2-heptyl-3-hydroxy-4(1H)-Quinolone (60 µM) increases secretion of the metabolite pyocyanin and the lectin PA-IL, as well as increases biofilm production in P. aeruginosa populations.[2] 2-heptyl-3-hydroxy-4(1H)-Quinolone (40 µM) reduces iron levels in P. aeruginosa growth media when used at a concentration and acts as an iron chelator in a Fe(III)-sulfate solution.[3] |
别名 | 2-heptyl-3-hydroxy-4(1H)-Quinolone, PQS, Pseudomonas Quinolone Signal |
分子量 | 259.34 |
分子式 | C16H21NO2 |
CAS No. | 108985-27-9 |
store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methanol: Soluble
DMSO: 12 mg/mL (46.27 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.8559 mL | 19.2797 mL | 38.5594 mL | 96.3986 mL |
5 mM | 0.7712 mL | 3.8559 mL | 7.7119 mL | 19.2797 mL | |
10 mM | 0.3856 mL | 1.928 mL | 3.8559 mL | 9.6399 mL | |
20 mM | 0.1928 mL | 0.964 mL | 1.928 mL | 4.8199 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
2-heptyl-3-hydroxy-4(1H)-Quinolone 108985-27-9 Others PQS Pseudomonas Quinolone Signal Inhibitor inhibitor inhibit