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Alextatug 是一种针对细胞质聚腺苷酸结合蛋白 1 (PABPC1) 的人源化单克隆抗体。PABPC1 是调节 mRNA 稳定性及翻译起始的关键蛋白,在多种恶性肿瘤中高表达。Alextatug 通过特异性结合 PABPC1,干扰其与 mRNA 及翻译起始复合物的相互作用,从而通过调节 Cell Cycle/Checkpoint 相关通路和 DNA/RNA Synthesis 过程来抑制肿瘤细胞的选择性增殖与转移。该抗体具有 Human IgG1 重链和 λ7 轻链结构,是研究翻译后基因表达调控的重要工具。
Alextatug 是一种针对细胞质聚腺苷酸结合蛋白 1 (PABPC1) 的人源化单克隆抗体。PABPC1 是调节 mRNA 稳定性及翻译起始的关键蛋白,在多种恶性肿瘤中高表达。Alextatug 通过特异性结合 PABPC1,干扰其与 mRNA 及翻译起始复合物的相互作用,从而通过调节 Cell Cycle/Checkpoint 相关通路和 DNA/RNA Synthesis 过程来抑制肿瘤细胞的选择性增殖与转移。该抗体具有 Human IgG1 重链和 λ7 轻链结构,是研究翻译后基因表达调控的重要工具。

| 产品描述 | Alextatug is a humanized monoclonal antibody targeting cytoplasmic polyadenylate-binding protein 1 (PABPC1). PABPC1 is a critical regulator of mRNA stability and translation initiation, often overexpressed in various malignancies. Alextatug specifically binds to PABPC1, disrupting its interaction with mRNA and translation initiation complexes. This action modulates Cell Cycle/Checkpoint-related pathways and DNA/RNA Synthesis processes to inhibit tumor cell proliferation and metastasis. Featuring a Human IgG1 heavy chain and λ7 light chain, this antibody serves as a tool for researching post-transcriptional gene regulation. |
| 反应种属 | Human |
| 应用 | ELISA FACS Functional assay |
| 抗体种类 | Monoclonal |
| 缓冲液 | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| 内毒素 | <1.0 EU/mg |
| 同型 | IgG1-REM-noK |
| 偶联 | Unconjugated |
| Uniprot ID | |
| 靶点 | PABPC1 |
| CAS No. | 2768264-93-1 |
| 存储 |
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