Glucocorticoid receptor modulator 1 is a highly effective and orally administered NF-κB and AP-1 inhibitor with IC50 values of 9 nM and 130 nM, respectively. It can downregulate the expression of inflammatory factors IL-6, IL-1β, TNF-α, and MMP-13, thereby alleviating skin inflammation.

方法：Glucocorticoid receptor modulator 1（10 μM，24 小时）处理RAW264.7细胞，qPCR检测相关mRNA的表达。
结果：Glucocorticoid receptor modulator 1降低 RAW264.7细胞中IL-6、IL-1β、TSLP、MMP-13、TNF-α 和 CCL-2 等炎症因子的 mRNA 表达。[1]