Name: Glucocorticoid receptor modulator 1
Brand: TargetMol
SKU: T72102
Price: 397 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 397

In stock

5 mg

¥ 986

In stock

10 mg

¥ 1,560

In stock

25 mg

¥ 3,130

In stock

50 mg

¥ 4,550

In stock

1 mL x 10 mM (in DMSO)

¥ 987

In stock

产品介绍

生物活性

产品描述	Glucocorticoid receptor modulator 1 is a highly effective and orally administered NF-κB and AP-1 inhibitor with IC50 values of 9 nM and 130 nM, respectively. It can downregulate the expression of inflammatory factors IL-6, IL-1β, TNF-α, and MMP-13, thereby alleviating skin inflammation.
体外活性	方法：Glucocorticoid receptor modulator 1（10 μM，24 小时）处理RAW264.7细胞，qPCR检测相关mRNA的表达。结果：Glucocorticoid receptor modulator 1降低 RAW264.7细胞中IL-6、IL-1β、TSLP、MMP-13、TNF-α 和 CCL-2 等炎症因子的 mRNA 表达。[1]
别名	Glucocorticoid receptor 调节剂 1

化学信息

分子量	470.97
分子式	C₂₄H₂₃ClN₂O₄S
CAS No.	2868357-11-1
Smiles	O=C(C=1C=CC=CC1)N2C3=CC=C(C=C3CCC2)NS(=O)(=O)C=4C=C(Cl)C(=CC4OC)C

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (169.86 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1233 mL	10.6164 mL	21.2328 mL	106.1639 mL
5 mM	0.4247 mL	2.1233 mL	4.2466 mL	21.2328 mL
10 mM	0.2123 mL	1.0616 mL	2.1233 mL	10.6164 mL
20 mM	0.1062 mL	0.5308 mL	1.0616 mL	5.3082 mL
50 mM	0.0425 mL	0.2123 mL	0.4247 mL	2.1233 mL
100 mM	0.0212 mL	0.1062 mL	0.2123 mL	1.0616 mL

体内实验配液计算器