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Siglec-2/CD22 Protein, Human, Recombinant (His & Avi), Biotinylated

Siglec-2/CD22 Protein, Human, Recombinant (His & Avi), Biotinylated

产品编号 TMPJ-00392
别名: T-cell surface antigen Leu-14, CD22 molecule, CD22, SIGLEC2FLJ22814, sialic acid binding Ig-like lectin 2, CD22 antigenMGC130020, B-cell receptor CD22, BL-CAM, Siglec-2, B-lymphocyte cell adhesion molecule

Siglec-2/CD22 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 110-130 KDa and the accession number is P20273.

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Siglec-2/CD22 Protein, Human, Recombinant (His & Avi), Biotinylated
规格 价格/CNY 货期 数量
20 μg ¥ 2,260 5日内发货
100 μg ¥ 6,130 5日内发货
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产品目录号及名称: Siglec-2/CD22 Protein, Human, Recombinant (His & Avi), Biotinylated (TMPJ-00392)
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生物活性
技术参数
产品性质
生物活性 Loaded Biotinylated Human Siglec-2-His-Avi on HIS1K Biosensor, can bind Anti-Human Siglec-2 mAb-Fc with an affinity constant of 0.16 nM as determined in BLI assay. (Regularly tested)
产品描述 Siglec-2/CD22 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 110-130 KDa and the accession number is P20273.
种属 Human
表达系统 HEK293 Cells
标签 C-6xHis-Avi
蛋白编号 P20273
别名 T-cell surface antigen Leu-14, CD22 molecule, CD22, SIGLEC2FLJ22814, sialic acid binding Ig-like lectin 2, CD22 antigenMGC130020, B-cell receptor CD22, BL-CAM, Siglec-2, B-lymphocyte cell adhesion molecule
氨基酸序列 Asp20-Arg687
蛋白构建 Asp20-Arg687
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 110-130 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Human Siglec-2, also known as B-cell antigen CD22 or B-lymphocyte cell adhesion molecule (BL-CAM), is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells. Two distinct human Siglec-2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated. Siglec-2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same (cis) or adjacent (trans) cells. Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis.

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Keywords

Siglec-2/CD22 Protein, Human, Recombinant (His & Avi), Biotinylated T-cell surface antigen Leu-14 CD-22 SIGLEC2FLJ-22814 CD22 antigenMGC-130020 CD22 molecule SIGLEC2FLJ 22814 CD22 SIGLEC2FLJ22814 sialic acid binding Ig-like lectin 2 CD22 antigenMGC130020 B-cell receptor CD22 CD 22 BL-CAM Siglec-2 B-lymphocyte cell adhesion molecule CD22 antigenMGC 130020 recombinant recombinant-proteins proteins protein

 

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