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Anti-CEACAM5 Antibody (3C451)

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Anti-CEACAM5 Antibody (3C451)
产品编号 TMAY-01606
别名 CEA, CD66e, carcinoembryonic antigen-related cell adhesion molecule 5

Anti-CEACAM5 Antibody (3C451) 是一种 Rabbit 抗体，靶向 CEACAM5。Anti-CEACAM5 Antibody (3C451) 可用于 FCM。

Anti-CEACAM5 Antibody (3C451)
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Anti-CEACAM5 Antibody (3C451)

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Anti-CEACAM5 Antibody (3C451)
产品编号 TMAY-01606 别名 CEA, CD66e, carcinoembryonic antigen-related cell adhesion molecule 5

Anti-CEACAM5 Antibody (3C451) 是一种 Rabbit 抗体，靶向 CEACAM5。Anti-CEACAM5 Antibody (3C451) 可用于 FCM。

规格价格库存数量
100 μL
¥ 2,284
5日内发货
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产品介绍

生物活性
产品描述
Anti-CEACAM5 Antibody (3C451) is a Rabbit antibody targeting CEACAM5. Anti-CEACAM5 Antibody (3C451) can be used in FCM.
别名CEA, CD66e, carcinoembryonic antigen-related cell adhesion molecule 5
Ig Type
Rabbit IgG
克隆号
3C451
交叉反应
Human
验证活性
Flow cytometric analysis of Human CEACAM5 expression on HT29 cells. Cells were stained with purified anti-Human CEACAM5, then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用
FCM
推荐剂量
FCM: 1:25-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human CEACAM5 / CD66e (rh CEACAM5 / CD66e; TMPY-01647; NP_004354.2; Met1-Ala685).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景CEACAM5, also known as CEA or CD66e, belongs to the large CEACAM subfamily of the immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with an MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domains and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
其他可选修饰符
APC/FITC/PE
可提供抗体种类
4
抗原信息
免疫原
Recombinant Protein: Human CEACAM5 / CD66e Protein (TMPY-01647)
抗原种属
Human
研究领域
Cancer Drug Targets
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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