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Anti-CD146/MCAM Antibody-APC (4Y548)
还可以产品编号 TMAY-00290A
Anti-CD146/MCAM Antibody-APC (4Y548) 是一种 APC-conjugated Mouse 抗体，靶向 CD146/MCAM。Anti-CD146/MCAM Antibody-APC (4Y548) 可用于 FCM。
Anti-CD146/MCAM Antibody-APC (4Y548)
Anti-CD146/MCAM Antibody-APC (4Y548)
还可以产品编号 TMAY-00290A
Anti-CD146/MCAM Antibody-APC (4Y548) 是一种 APC-conjugated Mouse 抗体，靶向 CD146/MCAM。Anti-CD146/MCAM Antibody-APC (4Y548) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD146/MCAM Antibody-APC (4Y548) is a APC-conjugated Mouse antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody-APC (4Y548) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4Y548 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD146 expression on HeLa cells. Cells were stained with APC-conjugated anti-Human CD146. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD146 / MCAM (rh CD146 / MCAM; TMPY-01034; NP_006491.2; Met 1-Gly 559) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas. |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human CD146 / MCAM protein (TMPY-01034) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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