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Anti-CD166/ALCAM Antibody-PE (3O275) 是一种 PE-conjugated Mouse 抗体,靶向 CD166/ALCAM。Anti-CD166/ALCAM Antibody-PE (3O275) 可用于 FCM。
Anti-CD166/ALCAM Antibody-PE (3O275) 是一种 PE-conjugated Mouse 抗体,靶向 CD166/ALCAM。Anti-CD166/ALCAM Antibody-PE (3O275) 可用于 FCM。
产品描述 | Anti-CD166/ALCAM Antibody-PE (3O275) is a PE-conjugated Mouse antibody targeting CD166/ALCAM. Anti-CD166/ALCAM Antibody-PE (3O275) can be used in FCM. |
Ig Type | Monoclonal Mouse IgG1 |
克隆号 | 3O275 |
交叉反应 | Human |
验证活性 | Profile of anti-ALCAM (CD166) reactivity on Jurkat cells analyzed by flow cytometry. |
应用 | FCM |
推荐剂量 | 10 μl/Test, 0.1 mg/ml |
抗体种类 | Monoclonal |
宿主来源 | Mouse |
构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD166 / ALCAM (rh CD166 / ALCAM; TMPY-01578; NP_001618.2; Met 1-Ala 526) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
研究背景 | Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target. |
偶联 | PE |
其他可选修饰符 | Unconjugated/APC/FITC |
可提供抗体种类 | 4 |
免疫原 | Recombinant Human CD166 / ALCAM protein (TMPY-01578) |
抗原种属 | Human |
储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
运输方式 | Shipping with blue ice. |
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