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Anti-CD50 Antibody-PE (5P32)
还可以产品编号 TMAY-00628P
Anti-CD50 Antibody-PE (5P32) 是一种 PE-conjugated Mouse 抗体，靶向 CD50。Anti-CD50 Antibody-PE (5P32) 可用于 FCM。
Anti-CD50 Antibody-PE (5P32)
Anti-CD50 Antibody-PE (5P32)
还可以产品编号 TMAY-00628P
Anti-CD50 Antibody-PE (5P32) 是一种 PE-conjugated Mouse 抗体，靶向 CD50。Anti-CD50 Antibody-PE (5P32) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD50 Antibody-PE (5P32) is a PE-conjugated Mouse antibody targeting CD50. Anti-CD50 Antibody-PE (5P32) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 5P32 |
| 交叉反应 | Human |
| 验证活性 | Profile of peripheral blood lymphocytes analyzed by flow cytometry. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD50 / ICAM-3 (rh CD50 / ICAM-3; TMPY-01430; CAA49369.1; Met 1-His 485) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | The protein ICAM-3, also known as CD50, is a member of the intercellular adhesion molecule (ICAM) family consisting of three members. It is a DC-SIGN ligand that is constitutively expressed on resting leukocytes and is thus an important molecule for the first immune response. ICAM-3 comprises five immunoglobulin-like domains and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule but also as a potent signaling molecule. ICAM-3 binds to LFA-1 on antigen-presenting cells (APC) stabilizing the T cell-APC interaction, facilitating signaling through the CD3/TCR complex. However, recent evidence using cultured and transformed T cells suggests ICAM-3 may also function in signaling. It has been reported that the CD50 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes. Also, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells. ICAM-3 is associated with an increase in cellular radio-resistance and cancer cell proliferation. It could be considered as a candidate for anti-cancer drug development and as a cancer diagnostic marker. |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC/FITC |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human ICAM3 / CD50 protein (TMPY-01430) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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