Name: Zorubicin
Brand: TargetMol
SKU: T69130
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 32,600

10-14周

50 mg

¥ 43,800

10-14周

100 mg

¥ 57,500

10-14周

生物活性

产品描述	Zorubicin (Rubidazon), a Daunorubicin derivative, inhibits DNA polymerases and interacts with topoisomerase II. It is utilized in the research of acute leukemias and sarcomas [1] [2] [3] [4] [5].
体外活性	H2-Gamendazole (H2-GMZ; 0-100 μM) was effective in rapidly blocking forskolin-induced, Cl-mediated short-circuit currents in human ADPKD cells, and it significantly inhibited both cAMP- and epidermal growth factor-induced proliferation of ADPKD cells.[1] H2-GMZ (50 μM)-treated ADPKD cells showed decreased phosphorylated ERK and decreased hyperphosphorylated retinoblastoma levels through western blot analysis.[1] H2-GMZ (50 μM; 24、48、72 h) treatment also decreased ErbB2, Akt, and cyclin-dependent kinase 4 and it decreased levels of the cystic fibrosis transmembrane conductance regulator Cl channel protein.[1]
体内活性	H2-Gamendazole (20 mg/kg; intraperitoneal injections) was effective in slowing postnatal cyst formation and kidney enlargement in the ---Pkd1flox/flox: Pkhd1-Cre mouse model.[1]
别名	Rubidazone, Rubidazon ; Rubidazone, Rubidazon

化学信息

分子量	645.66
分子式	C₃₄H₃₅N₃O₁₀
CAS No.	54083-22-6
Smiles	OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(=NNC(=O)C4=CC=CC=C4)C)(O)C2)C(O)=C5C1C(=O)C=6C(C5=O)=C(OC)C=CC6