Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zorubicin (Rubidazon) 是Daunorubicin 的衍生物。Zorubicin 与拓扑异构酶 II 相互作用,抑制DNA 聚合酶。Zorubicin 可用于急性白血病和肉瘤的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 32,600 | 10-14周 | ||
50 mg | ¥ 43,800 | 10-14周 | ||
100 mg | ¥ 57,500 | 10-14周 |
产品描述 | Zorubicin (Rubidazon), a Daunorubicin derivative, inhibits DNA polymerases and interacts with topoisomerase II. It is utilized in the research of acute leukemias and sarcomas [1] [2] [3] [4] [5]. |
体外活性 |
H2-Gamendazole (H2-GMZ; 0-100 μM) was effective in rapidly blocking forskolin-induced, Cl-mediated short-circuit currents in human ADPKD cells, and it significantly inhibited both cAMP- and epidermal growth factor-induced proliferation of ADPKD cells.[1] H2-GMZ (50 μM)-treated ADPKD cells showed decreased phosphorylated ERK and decreased hyperphosphorylated retinoblastoma levels through western blot analysis.[1] H2-GMZ (50 μM; 24、48、72 h) treatment also decreased ErbB2, Akt, and cyclin-dependent kinase 4 and it decreased levels of the cystic fibrosis transmembrane conductance regulator Cl channel protein.[1] |
体内活性 | H2-Gamendazole (20 mg/kg; intraperitoneal injections) was effective in slowing postnatal cyst formation and kidney enlargement in the ---Pkd1flox/flox: Pkhd1-Cre mouse model.[1] |
别名 | Rubidazon ; Rubidazone, Rubidazone, Rubidazon |
分子量 | 645.66 |
分子式 | C34H35N3O10 |
CAS No. | 54083-22-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Zorubicin 54083-22-6 MCMC-4222 RP 22050 Rubidazon ; Rubidazone MCMC4222 Rubidazone RP22050 MCMC 4222 Rubidazon ; Rubidazone Zorubicine. Rubidazone Rubidazon RP-22050 Inhibitor inhibitor inhibit