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EpCAM/TROP1 Protein, Human, Recombinant (hFc), Biotinylated

产品编号 TMPY-05117

别名: EGP314, DIAR5, TACSTD1, MK-1, KSA, MIC18, ESA, EGP40, epithelial cell adhesion molecule, EGP-2, KS1/4, TROP-1, M4S1, HNPCC8, TROP1

EpCAM/TROP1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is P16422.

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EpCAM/TROP1 Protein, Human, Recombinant (hFc), Biotinylated

规格	价格/CNY		货期	数量
20 μg	￥ 1,950		5日内发货
100 μg	￥ 4,620		5日内发货

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生物活性	Testing in progress
产品描述	EpCAM/TROP1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is P16422.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P16422
别名	EGP314, DIAR5, TACSTD1, MK-1, KSA, MIC18, ESA, EGP40, epithelial cell adhesion molecule, EGP-2, KS1/4, TROP-1, M4S1, HNPCC8, TROP1
蛋白构建	The EPCAM (NP_002345.1) (Met1-Lys265) was expressed with the fused Fc region of Human IgG1 at the C-terminus. The purified protein was biotinylated in vitro.
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	54.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing Sterile PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10. 2. Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5. 3. Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6. 4. Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.

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Keywords

EpCAM/TROP1 Protein, Human, Recombinant (hFc), Biotinylated EGP314 MIC 18 DIAR5 EGP2 HNPCC 8 EGP-40 TACSTD1 MK1 DIAR 5 HNPCC-8 MK-1 KSA MIC18 EGP 314 ESA EGP-314 DIAR-5 TACSTD 1 EGP40 epithelial cell adhesion molecule EGP-2 MIC-18 KS1/4 EGP 40 TROP-1 M4S1 MK 1 HNPCC8 TROP 1 EGP 2 TACSTD-1 TROP1 recombinant recombinant-proteins proteins protein

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