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Mitonafide

Name: Mitonafide
Brand: TargetMol
SKU: T25817
Price: 248 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.89%

货号 T25817Cas号 54824-17-8

别名 米托萘胺, NSC-300288, NSC300288, NSC 300288

Mitonafide (NSC-300288) 抑制 M. tuberculosis NAD+ 依赖性 DNA 连接酶 A 的活性。它是一种 DNA 嵌入剂。

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Mitonafide

一键复制产品信息

很棒

纯度: 99.89%

货号 T25817 别名 米托萘胺, NSC-300288, NSC300288, NSC 300288Cas号 54824-17-8

Mitonafide (NSC-300288) 抑制 M. tuberculosis NAD+ 依赖性 DNA 连接酶 A 的活性。它是一种 DNA 嵌入剂。

规格	价格	库存
1 mg	¥ 248	现货
5 mg	¥ 618	现货
10 mg	¥ 995	现货
25 mg	¥ 1,980	现货
50 mg	¥ 3,200	现货
100 mg	¥ 4,670	现货
200 mg	¥ 6,590	现货
1 mL x 10 mM (in DMSO)	¥ 455	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.89%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Mitonafide AI Summary

Mitonafide exhibits a variety of potent bioactivities, particularly related to DNA binding and antiproliferative effects against cancer cell lines. It has demonstrated DNA binding affinity comparable to ethidium bromide, with a C50 value of 11.0 µM and a dissociation constant (KD) of log 5.16. Furthermore, it shows significant cytotoxicity against multiple human cancer cell lines, including HT-29 with an IC50 of 600.0 nM, A549, SK-MEL-2, HL-60, and MCF-7, along with notable inhibition of cell growth in these lines. The compound's binding affinity, as measured by melting temperature changes, ranges with the highest Delta Tm of 17.2°C for specific DNA sequences, suggesting a role in stabilizing these structures. This compound also exhibits antiproliferative activity under hypoxic conditions in A375 and V79 cells. Additionally, it shows effective anticancer activity in xenografted mice models, with substantial inhibition of tumor growth at various doses. Mitonafide also disrupts specific molecular pathways and targets, including Nrf2 and Importin beta complex formation, indicating broad bioactivity and potential as an antitumor agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.
别名	米托萘胺, NSC-300288, NSC300288, NSC 300288

化学信息

分子量	313.31
分子式	C₁₆H₁₅N₃O₄
CAS No.	54824-17-8
Smiles	CN(C)CCN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O
密度	1.384g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 13 mg/mL (41.49 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1917 mL	15.9586 mL	31.9173 mL	159.5864 mL
5 mM	0.6383 mL	3.1917 mL	6.3835 mL	31.9173 mL
10 mM	0.3192 mL	1.5959 mL	3.1917 mL	15.9586 mL
20 mM	0.1596 mL	0.7979 mL	1.5959 mL	7.9793 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。