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Anti-CD166/ALCAM Antibody (5U804) 是一种 Mouse 抗体,靶向 CD166/ALCAM。Anti-CD166/ALCAM Antibody (5U804) 可用于 ELISA。
Anti-CD166/ALCAM Antibody (5U804) 是一种 Mouse 抗体,靶向 CD166/ALCAM。Anti-CD166/ALCAM Antibody (5U804) 可用于 ELISA。
产品描述 | Anti-CD166/ALCAM Antibody (5U804) is a Mouse antibody targeting CD166/ALCAM. Anti-CD166/ALCAM Antibody (5U804) can be used in ELISA. |
Ig Type | Monoclonal Mouse IgG1 |
克隆号 | 5U804 |
交叉反应 | Human |
应用 | ELISA |
推荐剂量 | ELISA: 1:1000-1:2000 |
抗体种类 | Monoclonal |
宿主来源 | Mouse |
构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD166 / ALCAM (rh CD166 / ALCAM; TMPY-01578; NP_001618.2; Met 1-Ala 526). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target. |
偶联 | Unconjugated |
免疫原 | Recombinant Human CD166 / ALCAM Protein (TMPY-01578) |
抗原种属 | Human |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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