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Anti-SIRT6 Antibody (6U297)
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产品编号 TMAC-03765
别名 SIRT6, SIR2-like protein 6, SIR2L6, Regulatory protein SIR2 homolog 6 (hSIRT6), Protein mono-ADP-ribosyltransferase sirtuin-6, NAD-dependent protein deacylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6
Anti-SIRT6 Antibody (6U297) 是一种 Rabbit 抗体，靶向 SIRT6。Anti-SIRT6 Antibody (6U297) 可用于 WB,ICC/IF,FCM。
Anti-SIRT6 Antibody (6U297)
Anti-SIRT6 Antibody (6U297)
还可以产品编号 TMAC-03765 别名 SIRT6, SIR2-like protein 6, SIR2L6, Regulatory protein SIR2 homolog 6 (hSIRT6), Protein mono-ADP-ribosyltransferase sirtuin-6, NAD-dependent protein deacylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6
Anti-SIRT6 Antibody (6U297) 是一种 Rabbit 抗体，靶向 SIRT6。Anti-SIRT6 Antibody (6U297) 可用于 WB,ICC/IF,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
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| 产品描述 | Anti-SIRT6 Antibody (6U297) is a Rabbit antibody targeting SIRT6. Anti-SIRT6 Antibody (6U297) can be used in WB,ICC/IF,FCM. |
| 别名 | SIRT6, SIR2-like protein 6, SIR2L6, Regulatory protein SIR2 homolog 6 (hSIRT6), Protein mono-ADP-ribosyltransferase sirtuin-6, NAD-dependent protein deacylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6 |
| Ig Type | IgG |
| 克隆号 | 6U297 |
| 交叉反应 | Human |
| 验证活性 | 1. ICC staining SIRT6 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 2. ICC staining SIRT6 in NIH/3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. Flow cytometric analysis of Hela cells with SIRT6 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000; ICC/IF: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The Silent Information Regulator (Sir2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of this family is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging. SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres, and gaps. SirT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 39 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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