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Anti-CD146/MCAM Antibody-APC (8V819)

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Anti-CD146/MCAM Antibody-APC (8V819)
产品编号 TMAY-00295A
别名 MUC18, melanoma cell adhesion molecule, CD146

Anti-CD146/MCAM Antibody-APC (8V819) 是一种 APC-conjugated Rabbit 抗体，靶向 CD146/MCAM。Anti-CD146/MCAM Antibody-APC (8V819) 可用于 FCM。

Anti-CD146/MCAM Antibody-APC (8V819)
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Anti-CD146/MCAM Antibody-APC (8V819)

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Anti-CD146/MCAM Antibody-APC (8V819)
产品编号 TMAY-00295A 别名 MUC18, melanoma cell adhesion molecule, CD146

Anti-CD146/MCAM Antibody-APC (8V819) 是一种 APC-conjugated Rabbit 抗体，靶向 CD146/MCAM。Anti-CD146/MCAM Antibody-APC (8V819) 可用于 FCM。

规格价格库存数量
25 T
¥ 895
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100 T
¥ 2,180
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产品介绍

生物活性
产品描述
Anti-CD146/MCAM Antibody-APC (8V819) is a APC-conjugated Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody-APC (8V819) can be used in FCM.
别名MUC18, melanoma cell adhesion molecule, CD146
Ig Type
Rabbit IgG
克隆号
8V819
交叉反应
Human
验证活性
Profile of anti-CD146 reactivity on HeLa cells analyzed by flow cytometry.
应用
FCM
推荐剂量
2 μl/Test, 0.1 mg/ml
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human CD146 / MCAM (rh CD146; TMPY-01034; NP_006491.2; Met 1-Gly 559) and conjugated with APC under optimum conditions, the unreacted APC was removed.
纯化方式Protein A
性状Liquid
缓冲液PBS solution containing 0.5% BSA and 0.03%ProClin300
研究背景The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas.
偶联与修饰
偶联
APC
其他可选修饰符
Unconjugated/HRP/PE
可提供抗体种类
4
抗原信息
免疫原
Recombinant Protein: Human CD146 protein (TMPY-01034)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight.
运输方式Shipping with blue ice.

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关键词

MUC-18MUC 18CD-146CD 146

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