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Anti-ICAM-1/CD54 Antibody (7X424)
还可以产品编号 TMAY-00664
Anti-ICAM-1/CD54 Antibody (7X424) 是一种 Mouse 抗体，靶向 ICAM-1/CD54。Anti-ICAM-1/CD54 Antibody (7X424) 可用于 ELISA,IHC-P。
Anti-ICAM-1/CD54 Antibody (7X424)
Anti-ICAM-1/CD54 Antibody (7X424)
还可以产品编号 TMAY-00664
Anti-ICAM-1/CD54 Antibody (7X424) 是一种 Mouse 抗体，靶向 ICAM-1/CD54。Anti-ICAM-1/CD54 Antibody (7X424) 可用于 ELISA,IHC-P。
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抗原信息
| 产品描述 | Anti-ICAM-1/CD54 Antibody (7X424) is a Mouse antibody targeting ICAM-1/CD54. Anti-ICAM-1/CD54 Antibody (7X424) can be used in ELISA,IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 7X424 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human ICAM-1 in human stomach with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human ICAM-1 in human kidney with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. |
| 应用 | ELISA,IHC-P |
| 推荐剂量 | ELISA: 1:1000-1:2000; IHC-P: 1:30-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICAM1 / CD54 extracellular domain (rh ICAM1; TMPY-01142; NP_000192.2; Met 1-Glu 480). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for some immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human ICAM-1 protein (TMPY-01142) |
| 抗原种属 | Human |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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