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Anti-CD146/MCAM Antibody (6W862)
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产品编号 TMAC-00660
别名 S-endo 1 endothelial-associated antigen, Melanoma-associated antigen MUC18, Melanoma-associated antigen A32, Melanoma cell adhesion molecule, Cell surface glycoprotein P1H12, Cell surface glycoprotein MUC18
Anti-CD146/MCAM Antibody (6W862) 是一种 Rabbit 抗体，靶向 CD146/MCAM。Anti-CD146/MCAM Antibody (6W862) 可用于 WB,ICC,IF,IHC,FCM。
Anti-CD146/MCAM Antibody (6W862)
Anti-CD146/MCAM Antibody (6W862)
还可以产品编号 TMAC-00660 别名 S-endo 1 endothelial-associated antigen, Melanoma-associated antigen MUC18, Melanoma-associated antigen A32, Melanoma cell adhesion molecule, Cell surface glycoprotein P1H12, Cell surface glycoprotein MUC18
Anti-CD146/MCAM Antibody (6W862) 是一种 Rabbit 抗体，靶向 CD146/MCAM。Anti-CD146/MCAM Antibody (6W862) 可用于 WB,ICC,IF,IHC,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
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| 产品描述 | Anti-CD146/MCAM Antibody (6W862) is a Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (6W862) can be used in WB,ICC,IF,IHC,FCM. |
| 别名 | S-endo 1 endothelial-associated antigen, Melanoma-associated antigen MUC18, Melanoma-associated antigen A32, Melanoma cell adhesion molecule, Cell surface glycoprotein P1H12, Cell surface glycoprotein MUC18 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of CD146 on SiHa cell using anti-CD146 antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-CD146 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD146 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-CD146 antibody. Counter stained with hematoxylin. 5. ICC staining CD146 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining CD146 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of HUVEC cells with CD146 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:500-1000; IHC: 1:50-200; ICC: 1:100-500; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The tumorigenic and metastatic phenotype of melanoma cells correlates well with an increased expression of cell-cell and cell-matrix adhesion receptors. The human Mel-CAM gene encodes a transmembrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. The deduced human sequence of 603 amino acids consists of a signal peptide, five immunoglobulin-like domains, a transmembrane region and a short cytoplasmic tail. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human mela-nomas and correlates well with development of metastatic disease. Mel-CAM activation initiates an outside-in signaling pathway that involves the protein tyrosine kinases Fyn, FAK and paxillin. Mel-CAM influences the dynamics of Actin cytoskeleton rearrangement and is essential for the maintenance of thymic architecture and function. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 72 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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