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Anti-EpCAM/TROP1 Antibody (7L889)
还可以产品编号 TMAY-01073
Anti-EpCAM/TROP1 Antibody (7L889) 是一种 Mouse 抗体，靶向 EpCAM/TROP1。Anti-EpCAM/TROP1 Antibody (7L889) 可用于 WB。
Anti-EpCAM/TROP1 Antibody (7L889)
Anti-EpCAM/TROP1 Antibody (7L889)
还可以产品编号 TMAY-01073
Anti-EpCAM/TROP1 Antibody (7L889) 是一种 Mouse 抗体，靶向 EpCAM/TROP1。Anti-EpCAM/TROP1 Antibody (7L889) 可用于 WB。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-EpCAM/TROP1 Antibody (7L889) is a Mouse antibody targeting EpCAM/TROP1. Anti-EpCAM/TROP1 Antibody (7L889) can be used in WB. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 7L889 |
| 交叉反应 | Human |
| 验证活性 | 1. Anti-EPCAM mouse monoclonal antibody at 1:500 dilution. -Lane A: A431 Whole Cell Lysate. -Lane B: MCF7 Whole Cell Lysate. -Lane C: HCT116 Whole Cell Lysate. -Lane D: COLO205 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:35 kDa. -Observed band size:40 kDa. 2. EPCAM was immunoprecipitated using: -Lane A:0.5 mg MCF-7 Whole Cell Lysate -0.5 µL anti-EPCAM mouse monoclonal antibody and 15 μl of 50 % Protein G agarose. -Primary antibody: -Anti-EPCAM mouse monoclonal antibody, at 1:500 dilution. -Secondary antibody: -Dylight 800-labeled antibody to Mouse IgG (H+L), at 1:7500 dilution. -Developed using the odyssey technique. -Performed under reducing conditions. -Predicted band size: 40 kDa. -Observed band size: 40 kDa |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1:1000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EpCAM / TROP1 (rh EpCAM; TMPY-01300; NP_002345.1; Met 1-Lys 265). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human EpCAM protein (TMPY-01300) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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