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Anti-FURIN Antibody (8Q583)
还可以产品编号 TMAH-00465
别名 PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme
Anti-FURIN Antibody (8Q583) 是一种抗体，靶向 FURIN。Anti-FURIN Antibody (8Q583) 可用于 ELISA, WB, IHC。
Anti-FURIN Antibody (8Q583)
Anti-FURIN Antibody (8Q583)
还可以产品编号 TMAH-00465 别名 PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme
Anti-FURIN Antibody (8Q583) 是一种抗体，靶向 FURIN。Anti-FURIN Antibody (8Q583) 可用于 ELISA, WB, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-FURIN Antibody (8Q583) is an antibody targeting FURIN. Anti-FURIN Antibody (8Q583) can be used in ELISA, WB, IHC. |
| 别名 | PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme |
| Ig Type | Rabbit IgG |
| 克隆号 | 8Q583 |
| 交叉反应 | Human |
| 验证活性 | 1. Western Blot -Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate, A375 whole cell lysate, HT-29 whole cell lysate, HepG2 whole cell lysate, U-87 whole cell lysate -All lanes: Furin antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 87 kDa -Observed band size: 87, 72 kDa 2. IHC image of TMAH-00465 diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISA, WB, IHC |
| 推荐剂量 | WB:1:500-1:5000; IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Secreted. Endosome membrane; Single-pass type I membrane protein. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32). (Microbial infection) Cleaves and activates diphtheria toxin DT. (Microbial infection) Cleaves and activates anthrax toxin protective antigen (PA). (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP. (Microbial infection) Facilitates human coronaviruses EMC and SARS-CoV-2 infections by proteolytically cleaving the spike protein at the monobasic S1/S2 cleavage site. This cleavage is essential for spike protein-mediated cell-cell fusion and entry into human lung cells. (Microbial infection) Facilitates mumps virus infection by proteolytically cleaving the viral fusion protein F. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Furin |
| 抗原种属 | Human |
| 基因ID | 5045 |
| Uniprot ID | |
| 研究领域 | Cell biology, Metabolism, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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