|
TMPY-04811
|
DKK1 Protein, Mouse, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 1,mdkk-1
|
Mouse
|
HEK293
|
|
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori... |
|
TMPY-01174
|
DKK1 Protein, Rhesus, Recombinant (N256Q, His)
dickkopf WNT signaling pathway inhibitor 1
|
Rhesus
|
HEK293
|
|
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori... |
|
TMPY-01121
|
DKK3 Protein, Mouse, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 3,C87148,A...
|
Mouse
|
HEK293
|
|
DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its... |
|
TMPY-00775
|
DKK1 Protein, Human, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 1,SK,DKK-1
|
Human
|
HEK293
|
|
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori... |
|
TMPY-01030
|
TFPI Protein, Human, Recombinant (His)
TFPI1,tissue factor pathway inhibitor (lipoprotein-...
|
Human
|
HEK293
|
|
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is... |
|
TMPY-05797
|
DKK1 Protein, Rat, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 1
|
Rat
|
HEK293
|
|
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori... |
|
TMPY-06377
|
DKK3 Protein, Human, Recombinant
REIC,dickkopf WNT signaling pathway inhibitor 3,RIG
|
Human
|
HEK293
|
|
DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its... |
|
TMPY-01175
|
DKK1 Protein, Rhesus, Recombinant (N256Q, mFc)
dickkopf WNT signaling pathway inhibitor 1
|
Rhesus
|
HEK293
|
|
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori... |
|
TMPY-02329
|
TFPI2 Protein, Mouse, Recombinant (His)
tissue factor pathway inhibitor 2,PP5/TFPI-2,AV0006...
|
Mouse
|
HEK293
|
|
Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 is highly abundant in the full-term placenta and widely expressed in va... |
|
TMPY-02859
|
TFPI2 Protein, Mouse, Recombinant (hFc)
PP5/TFPI-2,AV000670,tissue factor pathway inhibitor...
|
Mouse
|
HEK293
|
|
Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 is highly abundant in the full-term placenta and widely expressed in va... |
|
TMPY-00950
|
WISP1/CCN4 Protein, Human, Recombinant (His)
WISP1c,WISP1i,CCN4,WNT1 inducible signaling pathway...
|
Human
|
HEK293
|
|
CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a ... |
|
TMPY-05479
|
DKK1 Protein, Human, Recombinant (hFc)
dickkopf WNT signaling pathway inhibitor 1,DKK-1,SK
|
Human
|
HEK293
|
|
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori... |
|
TMPY-05179
|
TFPI Protein, Human, Recombinant (His), Biotinylated
TFI,TFPI1,EPI,LACI,tissue factor pathway inhibitor ...
|
Human
|
HEK293
|
|
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is... |
|
TMPY-01004
|
TFPI2 Protein, Human, Recombinant (His)
REF1,PP5,tissue factor pathway inhibitor 2,TFPI-2
|
Human
|
HEK293
|
|
Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 is highly abundant in the full-term placenta and widely expressed in va... |
|
TMPY-00928
|
TFPI Protein, Mouse, Recombinant (His)
AW552122,A630013F22Rik,tissue factor pathway inhibi...
|
Mouse
|
HEK293
|
|
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is... |
|
TMPY-01147
|
R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)
RSPO,CRISTIN3,R-spondin 1
|
Human
|
HEK293
|
|
RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts... |
|
TMPY-03197
|
R-Spondin 1/RSPO1 Protein, Mouse, Recombinant (His)
R-spondin,R-spondin 1,Rspondin
|
Mouse
|
CHO
|
|
RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts... |
|
TMPY-03626
|
R-Spondin 1/RSPO1 Protein, Human, Recombinant
RSPO,R-spondin 1,CRISTIN3
|
Human
|
CHO
|
|
RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts... |
|
TMPY-05081
|
Notch 1 Protein, Human, Recombinant (hFc)
notch 1,TAN1,hN1,AOVD1,AOS5
|
Human
|
HEK293
|
|
NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair the regeneration of skeletal muscles.NOTCH1 is a prevalent signaling pathway in T cell acute lymphoblastic leukemia (T-ALL). The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems. The pro... |
|
TMPY-06418
|
R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc)
R-spondin 2,CRISTIN2
|
Human
|
HEK293
|
|
R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts a... |
|
TMPY-02028
|
RON/CD136 Protein, Human, Recombinant (His)
CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON
|
Human
|
HEK293
|
|
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in... |
|
TMPY-00680
|
BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant (hFc)
bone morphogenetic protein 2
|
Human,Mouse,Rat,Rhesus,Canine
|
HEK293
|
|
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 pr... |
|
TMPY-02879
|
IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158)
interleukin 36, alpha,白细胞介素,FIL1(ε),IL1(ε),白介素,IL1E,IL-1F6,F...
|
Human
|
E. coli
|
|
Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine that plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB i... |
|
TMPY-04874
|
IL-23 P19/IL23A Protein, Human, Recombinant (hFc)
IL-23A,IL-23,interleukin 23, alpha subunit p19,SGRF,IL23P19,...
|
Human
|
HEK293
|
|
IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling ... |
|
TMPY-01429
|
RELT/TNFRSF19L Protein, Human, Recombinant (His)
TRLT,TNFRSF19L,RELT tumor necrosis factor receptor
|
Human
|
HEK293
|
|
Receptor expressed in lymphoid tissues (RELT), also known as tumor necrosis factor receptor superfamily, member 19-like (TNFRSF19L), is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1. RELT/TNFRSF19L is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. REL... |
|
TMPY-04153
|
RNF43 Protein, Human, Recombinant (His)
ring finger protein 43,URCC,RNF43,RNF124
|
Human
|
HEK293
|
|
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. |
|
TMPY-00686
|
Complement C2 Protein, Human, Recombinant (His)
CO2,complement component 2,ARMD14
|
Human
|
HEK293
|
|
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in extrahepatic tissues. This pathway is triggered by a multimolecular complex C1, and subsequently the single-chain form of C2 is cleaved into two chains referred to C2a and C2b by activated C1. The second component of complement (C2) is a multi-domain serine protease that provides ca... |
|
TMPY-01081
|
SR-BI/SCARB1 Protein, Human, Recombinant (His)
SR-BI,SRB1,HDLQTL6,CD36L1,CLA-1,scavenger receptor class B, ...
|
Human
|
HEK293
|
|
Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane. SCARB1 is proposed as a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells, and is involved in a wide variety of physilogica... |
|
TMPY-02481
|
ACOX1 Protein, Human, Recombinant (His)
PALMCOX,ACOX,SCOX,acyl-CoA oxidase 1, palmitoyl
|
Human
|
Baculovirus-Insect Cells
|
|
Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a... |
|
TMPY-01101
|
Coagulation factor X/F10 Protein, Human, Recombinant (His)
FXA,FX,coagulation factor X,coagulation factor 10
|
Human
|
Baculovirus-Insect Cells
|
|
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hema... |
|
TMPY-05435
|
ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc)
angiopoietin 1,AGPT,AGP1,ANG1
|
Human
|
HEK293
|
|
The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures... |
|
TMPY-05242
|
CRLF2/TSLPR Protein, Human, Recombinant (His)
CRL2,CRLF2Y,TSLPR,cytokine receptor-like factor 2
|
Human
|
HEK293
|
|
Overexpression of cytokine receptor-like factor 2 (CRLF2) due to chromosomal rearrangement has been observed in acute lymphoblastic leukemia (ALL) and reported to contribute to oncogenesis and unfavorable outcome in ALL. The high CRLF2 expression works with the IKZF1 deletion to drive oncogenesis of ALL and has significance in an integrated prognostic model for adult high-risk ALL. Thymic stromal lymphopoietin (TSLP) stimulates in-vitro proliferation of human fetal B-cell precursors. However, it... |
|
TMPY-04830
|
GAS6 Protein, Mouse, Recombinant (His)
growth arrest-specific 6,Gas-6
|
Mouse
|
HEK293
|
|
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor... |
|
TMPY-05156
|
ICOS Protein, Human, Recombinant (rFc)
inducible T-cell co-stimulator,AILIM,CVID1,CD278
|
Human
|
HEK293
|
|
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4, and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which are essential for the germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. Also, ICOS is more potent i... |
|
TMPY-02473
|
ICOS Protein, Mouse, Recombinant (hFc)
H4,CRP-1,AILIM,Ly115,CCLP,inducible T-cell co-stimulator
|
Mouse
|
HEK293
|
|
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4, and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which are essential for the germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. Also, ICOS is more potent i... |
|
TMPY-02279
|
Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His)
PUNP,PRO1837,purine nucleoside phosphorylase,NP
|
Human
|
E. coli
|
|
Purine nucleoside phosphorylase (PNP) is a purine-metabolizing enzyme that catalyzes the reversible phosphorolysis of 6-oxypurine (deoxy)nucleosides to their respective bases and (deoxy)ribose-1-phosphate. It is a key enzyme in the purine salvage pathway of mammalian cells. Purine nucleoside phosphorylase is a transferase that catalyzes the addition of phosphate and removal of a purine base from guanosine and similar nucleosides.PNP defects result in metabolic abnormalities and fatal T cell immu... |
|
TMPY-01750
|
HVEM Protein, Human, Recombinant (His)
HVEA,TR2,HVEM,ATAR,tumor necrosis factor receptor superfamil...
|
Human
|
HEK293
|
|
Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent st... |
|
TMPY-03565
|
Mannan Binding Lectin/MBL2 Protein, Human, Recombinant
MBPD,MBP-C,mannose-binding lectin (protein C) 2, soluble,COL...
|
Human
|
CHO
|
|
MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defense. They bind sugar structures or acetylated compounds present on microorganisms and dying host c... |
|
TMPY-01281
|
ACVR2B Protein, Mouse, Recombinant (His)
ActRIIB,activin A receptor, type IIB,4930516B21Rik
|
Mouse
|
HEK293
|
|
ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other c... |
|
TMPY-00392
|
PAM Protein, Human, Recombinant (His)
PAL,peptidylglycine alpha-amidating monooxygenase,peptidylgl...
|
Human
|
HEK293
|
|
Peptidylglycine alpha-amidating monooxygenase (PAM) is highly expressed in neurons and endocrine cells, where it catalyzes one of the final steps in the biosynthesis of bioactive peptides. PAM is also expressed in unicellular organisms such as Chlamydomonas reinhardtii, which do not store peptides in secretory granules. As for other granule membrane proteins, PAM is retrieved from the cell surface and returned to the trans-Golgi network. This pathway involves regulated entry of PAM into multives... |
|
TMPY-02361
|
VEGFR2/KDR Protein, Human, Recombinant (His)
VEGFR2,kinase insert domain receptor,VEGFR,FLK1,Flk-1,CD309
|
Human
|
HEK293
|
|
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... |
|
TMPY-01084
|
TrkA Protein, Human, Recombinant (His)
TRK1,TRK,TRKA,neurotrophic tyrosine kinase, receptor, type 1...
|
Human
|
HEK293
|
|
TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by the pluripotent neural stem and neural crest progenitors. The prese... |
|
TMPY-00654
|
ACVR2B Protein, Human, Recombinant (hFc)
activin A receptor, type IIB,HTX4,ActR-IIB,ACTRIIB,Activin R...
|
Human
|
HEK293
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ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other c... |
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TMPY-05592
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ULBP-2 Protein, Human, Recombinant(aa 1-217, His&AVI),Biotinylated
ALCAN-α,NKG2DL2,RAET1H,UL16 binding protein 2,N2DL2,ALCAN-al...
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Human
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HEK293
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NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cy... |
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TMPY-00742
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EGFR Protein, Human, Recombinant (His)
mENA,NISBD2,ERBB1,HER1,PIG61,ERBB,epidermal growth factor re...
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Human
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HEK293
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As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MA... |
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TMPY-00369
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LY6D Protein, Human, Recombinant (mFc)
E48,lymphocyte antigen 6 complex, locus D,Ly-6D
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Human
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HEK293
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LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. The expression of LY6D is induced in MCF10A cells by X-ray irradiation. The induction of LY6D expression is triggered through a pathway regulated by ATM, CHK2, and p53. This method is a new Ab-directed proteomic strategy for the analysis of membrane protein... |
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TMPY-01725
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Leptin Receptor Protein, Human, Recombinant (His)
LEPRD,OB-R,OBR,LEP-R,CD295,leptin receptor
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Human
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HEK293
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Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight) and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART ne... |
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TMPY-02676
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EGFR Protein, Mouse, Recombinant (His)
Errp,AI552599,Errb1,9030024J15Rik,wa2,Erbb,wa-2,Wa5,epiderma...
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Mouse
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HEK293
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As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MA... |
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TMPY-04818
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EGFR Protein, Cynomolgus, Recombinant (His)
epidermal growth factor receptor
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Cynomolgus
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HEK293
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As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MA... |
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TMPY-02333
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ULBP-2 Protein, Human, Recombinant (His)
ALCAN-α,UNQ463 / PRO791,NKG2DL2,ALCAN-alpha,UL16 binding pro...
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Human
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HEK293
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NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cy... |
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