Name: Ociperlimab
Brand: TargetMol
SKU: T78324
Price: 10300 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,300

现货

5 mg

¥ 5,250

现货

10 mg

¥ 7,080

现货

25 mg

¥ 10,300

现货

50 mg

待询

现货

生物活性

产品描述	Ociperlimab (BGB-A1217) is a novel humanized monoclonal antibody targeting TIGIT that exhibits antitumor activity. Ociperlimab blocks the TIGIT/PVR signaling pathway with high affinity and, through its Fc effector functions, synergistically enhances antitumor immune responses via multiple mechanisms. Ociperlimab is indicated for the treatment of advanced solid tumors.
靶点活性	TIGIT:0.135 nM (Kd)
体外活性	Ociperlimab (0-10 μg/mL)处理，增加巨细胞病毒特异性 T 细胞分泌 IFN-γ。 Ociperlimab（1-1000 ng/mL）以 FC 依赖的方式激活自然杀伤细胞和单核细胞。 Ociperlimab 通过体外 FC 依赖性内吞作用从T细胞表面去除 TIGIT。[1]
体内活性	Ociperlimab （3 和 10 mg/kg; 腹腔注射）处理 CT26 WT 荷瘤人源化 TIGIT 敲入小鼠和 MC38 荷瘤人源化 TIGIT 敲入小鼠，结果显示 Ociperlimab 以 Fc 依赖性方式产生抗肿瘤功效。[1]
别名	欧司珀利单抗, WCD-118, WCD118, BGB-A1217, BGBA1217
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	Human IgG1 kappa
推荐同型对照	Human IgG1 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

分子量	145.12 kDa
CAS No.	2342597-93-5

储存&溶解度

存储	Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Ociperlimab