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LRP-6 Protein, Human, Recombinant (mFc)
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货号 TMPK-00744
别名 LRP-6, LRP6, FLJ90421, FLJ90062, DCAD2
Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin. LRP-6 Protein, Human, Recombinant (mFc) is expressed in HEK293 Cells. The accession number is O75581-1.
其他形式的 “LRP-6 Protein, Human, Recombinant (mFc)”:
LRP-6 Protein, Human, Recombinant (mFc)
一键复制产品信息 还可以SPR兼容缓冲液
货号 TMPK-00744 别名 LRP-6, LRP6, FLJ90421, FLJ90062, DCAD2
Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin. LRP-6 Protein, Human, Recombinant (mFc) is expressed in HEK293 Cells. The accession number is O75581-1.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 μg | ¥ 283 | 6-8日内发货 | |
| 10 μg | ¥ 446 | 6-8日内发货 | |
| 20 μg | ¥ 723 | 5日内发货 | |
| 50 μg | ¥ 1,380 | 5日内发货 | |
| 100 μg | ¥ 2,360 | 5日内发货 | |
| 200 μg | ¥ 4,280 | 5日内发货 | |
| 500 μg | ¥ 9,490 | 5日内发货 |
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| 产品描述 | Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin. LRP-6 Protein, Human, Recombinant (mFc) is expressed in HEK293 Cells. The accession number is O75581-1. |
| 生物活性 | Immobilized Human DKK1, His Tag at 5 μg/mL (100 μL/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 0.58 μg/mL determined by ELISA. Immobilized Human SOST, His Tag at 2 μg/mL (100 μL/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 13.1 ng/mL determined by ELISA. Immobilized Human LRP-6, mFc Tag at 5 μg/mL (100 μL/well) on the plate. Dose response curve for Human R spondin 1, His Tag with the EC50 of 4.4 μg/mL determined by ELISA. |
| 研究背景 | Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin. |
| 种属 | Human |
| 表达系统 | HEK293 Cells |
| 标签 | C-mFc (IgG2a) |
| 蛋白编号 | O75581-1 |
| 蛋白构建 | Ala20-Pro630 |
| 蛋白纯度 | > 90% as determined by Tris-Bis PAGE |
| 蛋白性状 | Solution |
| 缓冲液 | Supplied as 0.22 μm filtered solution in PBS (pH 7.4). |
| 别名 | LRP-6, LRP6, FLJ90421, FLJ90062, DCAD2 |
| 内毒素 | < 1 EU/μg by the LAL method. |
| 分子量 | 95.32 kDa (predicted); 97-110 kDa (Bis-Tris PAGE, due to glycosylation) |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
| 存储 | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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