Name: Sudubrilimab
Brand: TargetMol
SKU: T77189
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 mg

待询

生物活性

产品描述	Sudubrilimab is an innovative bifunctional fusion protein designed to simultaneously target two key inhibitory pathways in the tumor microenvironment: the PD-1/PD-L1 immune checkpoint and the TGF-beta signaling axis. The compound consists of a humanized anti-PD-L1 monoclonal antibody fused to the extracellular domain of TGF-beta receptor II (TGFBR2-ECD). Serving as an essential tool for investigating the reversal of tumor immunosuppression and the enhancement of effector cell function, its design aims to overcome resistance to single-target therapies through synergistic action.
体外活性	在 PD-L1 和 TGF-beta 结合实验中，Sudubrilimab 特异性结合这两个靶标，并在 T 细胞活化实验中增强了 IFN-gamma 的产生 [1]。
别名	舒度利单抗, HS636
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q9NZQ7
靶点	PD-L1

化学信息

CAS No.

2387417-06-1

储存&溶解度

存储	store at low temperature \| store at -20°C \| Shipping with blue ice/Shipping at ambient temperature.（实际储存温度请以该批次产品标识为准）

Sudubrilimab