Name: Ganglioside GM2
Brand: TargetMol
SKU: T82340
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

待询

5 mg

待询

生物活性

产品描述	Ganglioside GM2 is a component of the cell membrane's glycosphingolipid bilayer and a human tumor antigen (OFA-I-1). It accumulates and increases in models of Sandhoff disease, Niemann-Pick disease, and Tay-Sachs disease, among others. Ganglioside GM2 binds to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, thereby promoting tumor cell migration and invasion.
体外活性	Ganglioside GM2 (25 μM，24 小时) 显著提升SK-RC-45肿瘤细胞的迁移和侵袭能力[1]。
别名	神经节苷脂 GM2

化学信息

分子量	1384.68
分子式	C₆₇H₁₂₁N₃O₂₆
CAS No.	127663-77-8
Smiles	O([C@@]1(C(O)=O)O[C@@]([C@@H]([C@@H](CO)O)O)([C@H](NC(C)=O)[C@@H](O)C1)[H])[C@H]2[C@@H](O[C@H]3[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)[C@@H](CO)O[C@@H](O[C@@H]4[C@@H](CO)O[C@@H](OC[C@H](NC(CCCCCCCCCCCCCCCCC)=O)[C@@H](/C=C/CCCCCCCCCCCCC)O)[C@H](O)[C@H]4O)[C@@H]2O
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 10 mg/mL (7.22 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7222 mL	3.6109 mL	7.2219 mL	36.1094 mL
5 mM	0.1444 mL	0.7222 mL	1.4444 mL	7.2219 mL

Ganglioside GM2