keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
P8RI (D-P8RI) is a CD31 biomimetic peptide and agonist that specifically targets the juxtamembrane amino acid sequence of the ectodomain of CD31. By restoring the CD31 inhibitory pathway, P8RI exhibits immunosuppressive properties. 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 P8RI acetate 的水溶性和稳定性通常比游离态更好。
产品描述 | P8RI (D-P8RI) is a CD31 biomimetic peptide and agonist that specifically targets the juxtamembrane amino acid sequence of the ectodomain of CD31. By restoring the CD31 inhibitory pathway, P8RI exhibits immunosuppressive properties. |
体外活性 | P8RI (D-P8RI) was designed as a retro-inverso peptide with all-D-amino acids allowing to maintain bioactivity and to confer resistance towards plasma proteases[1]. |
体内活性 | P8RI (2.5 mg/kg; s.c.; daily from 7 to 28 after the occurrence of ADIM) prevents aneurysmal transformation by promoting the resolution of intramural hematoma and the production of collagen in dissected aortas in vivo, associated with enrichment of M2 macrophages at the site of injury[3]. Animal Model: Apo E -/- mice (male, 28-week-old) implanted with Ang II-releasing pumps (a model of experimental acute aortic dissection and intramural hematoma (ADIM))[3]Dosage: 2.5 mg/kg Administration: Subcutaneous injection; daily from 7 to 28 (after the implantation of the osmotic pump delivering Ang II) Result: Aneurysmal transformation was significantly reduced. |
别名 | D-P8RI |
分子量 | 1016.259 |
分子式 | C51H77N13O9 |
CAS No. | 2147724-76-1 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
P8RI 2147724-76-1 D-P8RI P-8RI Inhibitor inhibitor inhibit