Name: P8RI
Brand: TargetMol
SKU: T39615
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

200 mg

¥ 10,191

待询

生物活性

产品描述	P8RI (D-P8RI) is a CD31 biomimetic peptide and agonist that specifically targets the juxtamembrane amino acid sequence of the ectodomain of CD31. By restoring the CD31 inhibitory pathway, P8RI exhibits immunosuppressive properties.
体外活性	P8RI (D-P8RI) was designed as a retro-inverso peptide with all-D-amino acids allowing to maintain bioactivity and to confer resistance towards plasma proteases[1].
体内活性	P8RI (2.5 mg/kg; s.c.; daily from 7 to 28 after the occurrence of ADIM) prevents aneurysmal transformation by promoting the resolution of intramural hematoma and the production of collagen in dissected aortas in vivo, associated with enrichment of M2 macrophages at the site of injury[3]. Animal Model: Apo E -/- mice (male, 28-week-old) implanted with Ang II-releasing pumps (a model of experimental acute aortic dissection and intramural hematoma (ADIM))[3]Dosage: 2.5 mg/kg Administration: Subcutaneous injection; daily from 7 to 28 (after the implantation of the osmotic pump delivering Ang II) Result: Aneurysmal transformation was significantly reduced.
别名	D-P8RI

化学信息

分子量	1016.259
分子式	C₅₁H₇₇N₁₃O₉
CAS No.	2147724-76-1
Smiles	CC(C)C[C@@H](NC(=O)[C@@H](C)NC(=O)[C@H]1CCCN1C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCNC(N)=N)C(O)=O
Sequence	H-D-Lys-D-Trp-D-Pro-D-Ala-D-Leu-D-Phe-D-Val-D-Arg-OH
Sequence Short	KWPALFVR

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

P8RI