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AKR1B1 Protein, Human, Recombinant (His)

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货号 TMPY-02438

别名 MGC1804, AR, ALR2, ALDR1, aldo-keto reductase family 1, member B1 (aldose reductase), ADR

Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. Some human tissues contain AKR1B1 as well as AKR1B10, a closely related member of the aldo-keto reductase superfamily.

AKR1B1 Protein, Human, Recombinant (His)
其他形式的 “AKR1B1 Protein, Human, Recombinant (His)”:
Amphiregulin Protein, Human, Recombinant
Amphiregulin Protein, Human, Recombinant (hFc)
Amphiregulin Protein, Mouse, Recombinant (hFc)
AKR1A1 Protein, Human, Recombinant (His)

AKR1B1 Protein, Human, Recombinant (His)

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Rating icon 还可以
货号 TMPY-02438 别名 MGC1804, AR, ALR2, ALDR1, aldo-keto reductase family 1, member B1 (aldose reductase), ADR

Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. Some human tissues contain AKR1B1 as well as AKR1B10, a closely related member of the aldo-keto reductase superfamily.

规格价格库存数量
5 μg
¥ 669
6-8日内发货
10 μg
¥ 1,080
6-8日内发货
20 μg
¥ 1,830
5日内发货
50 μg
¥ 3,660
5日内发货
100 μg
¥ 6,200
5日内发货
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选择批次:
纯度: ≥ 90 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
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资源下载:
COA重组蛋白用户指南

产品介绍

生物活性
产品描述
Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. Some human tissues contain AKR1B1 as well as AKR1B10, a closely related member of the aldo-keto reductase superfamily.
生物活性
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景
Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. Some human tissues contain AKR1B1 as well as AKR1B10, a closely related member of the aldo-keto reductase superfamily.
种属
Human
表达系统
E. coli
标签N-His
蛋白编号P15121
蛋白构建A DNA sequence encoding the human AKR1B1 (P15121) (Met 1-Phe 316) was expressed, with a polyhistidine tag at the N-terminus. Predicted N terminal: Met
蛋白纯度
> 90 % as determined by SDS-PAGE
蛋白性状Solution
缓冲液Supplied as sterile PBS, 20% glycerol, pH 7.5.
复溶方法A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
别名MGC1804, AR, ALR2, ALDR1, aldo-keto reductase family 1, member B1 (aldose reductase), ADR
内毒素Please contact us for more information.
化学信息
分子量37.9 kDa (predicted); 36 kDa (reducing conditions)
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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剂量转换

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技术支持

请阅读 重组蛋白用户指南 了解更多具体信息.

关键词

MGC-1804MGC 1804ALR-2ALR 2ALDR-1ALDR 1aldose reductasealdo-keto reductase family 1, member B1
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