Propoxur-d7 is the deuterium-labeled version of Propoxur. Propoxur serves as a reversible, competitive acetylcholinesterase (AChE) inhibitor that can be administered orally and cross the blood-brain barrier. It inhibits AChE activity, causing neurotoxicity, and simultaneously induces intracellular ROS production, activates the ERK/Nrf2 signaling pathway, promotes MMP-2 expression, and enhances the migration and invasion capabilities of tumor cells. While Propoxur inhibits AChE, leading to acetylcholine accumulation and neural dysfunction, it also facilitates ROS-dependent ERK1/2 phosphorylation, promoting nuclear translocation of Nrf2 and upregulation of invasion-related proteins like MMP-2. Additionally, Propoxur is an insecticide in the carbamate class used for controlling turf, forestry, and household pests.

拜力坦-d7