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BMP-7 Protein, Human, Recombinant

产品编号 TMPJ-01473BMP-7 Protein, Human, Recombinant

Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions.

BMP-7 Protein, Human, Recombinant

BMP-7 Protein, Human, Recombinant

产品编号 TMPJ-01473BMP-7 Protein, Human, Recombinant
Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions.
规格价格库存数量
10 μg
¥ 1,970
期货
50 μg
¥ 7,415
期货
500 μg
¥ 37,115
期货
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实验操作小课堂
BMP-7 Protein, Human, Recombinant产品问题解答
请问 BMP-7 Protein, Human, Recombinant 分子量是多少?
分子量是18 kd (根据胶图仪器分析,分子量18 kd的占比95.17%,分子量22 kd的占比4.83%,都是目标蛋白,应该是不同糖基化修饰,所以我们 COA 上写的分子量是18-22 kd)。
常见问题解答
购买多次产品,发现颜色不同,怎么办?
首先请您确认批次,如果是同一个批次产品,请联系技术同事核查产品颜色。如果是不同批次,请您放心,颜色不同可能是生产工艺不同而造成的,生产过程中的操作、温度、时间等因素可能会影响产品的颜色。如果您对该批次有疑虑,可在官网下载相应的质检报告,我们是对产品质量负责的。
得到的杀死细胞的 IC50 与网页上 IC50 差距较大怎么办?
您所测试的IC50是指细胞的增殖抑制实验(半抑制率),细胞增殖抑制实验 IC50值,和网页上的靶点IC50其实是不同的意义。文献里和网页上 IC50其实往往是指对于靶点无细胞实验的抑制率,这样的实验一般是通过激酶或者蛋白纯化实验做出来的,nM 级别的浓度比较常见,但是细胞的增殖抑制实验 IC50 是指细胞的半致死率,同时牵涉到细胞的代谢以及渗透,一般浓度会高一些。 另外,同一个化合物对不同细胞模型的效果也是不同的,建议尝试增加孵育量、延长孵育时间。
产品的溶解度是多少?
建议您先查询TargetMol官网、陶术官网,看该抑制剂的产品介绍,找到溶解度信息。如果没有相应信息,建议联系技术对该化合物的溶解度进行测定。
期货产品没有纯度啊?这个纯度在哪里看
期货产品的话,是没有纯度信息,也没有质检信息的。有了现货之后我们会进行质检,测出试剂的纯度和结构等相关信息,并且展示在官网的活性描述上方。
超声一般需要多久?
超声时长和溶解的量和浓度都有关,一般建议半个小时左右,如果浓度接近最大溶解度,或者需溶解的粉末较多,建议延长超声时间,并辅以加热。
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产品信息

生物活性
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述
Recombinant Human Bone morphogenetic protein 7 is produced by our Mammalian expression system and the target gene encoding Ser293-His431 is expressed.
种属
Human
表达系统
HEK293 Cells
标签Tag Free
蛋白编号P18075
别名
Osteogenic protein 1,OP-1,OP1,Eptotermin alfa,Bone morphogenetic protein 7,BMP7
氨基酸序列
Ser293-His431
蛋白构建
Ser293-His431
蛋白纯度
Greater than 95% as determined by reducing SDS-PAGE.
分子量18-23 KDa (reducing condition)
内毒素< 1 EU/μg by the LAL method.
缓冲液Supplied as a 0.2 μm filtered solution of 20 mM PB, 100 mM NaCl, 5% Mannitol, 0.05% Tween 80, pH7.5.
存储
It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 6 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景
Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions.

参考文献

SCI 文献

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