Name: LUF7996
Brand: TargetMol
SKU: T215953
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	LUF7996 is a CCR2-targeting PROTAC degrader with a DC50 of 2.6 μM, designed to degrade CCR2 effectively. It binds simultaneously to CCR2 and the E3 ligase cereblon, demonstrating sustained and concentration-dependent degradation of CCR2. The compound induces CCR2 degradation via the lysosomal pathway and effectively inhibits monocyte migration in vitro.
靶点活性	CCR2:2.6 μM (DC50)
体外活性	LUF7996 是靶向 CCR2 PROTAC 的降解剂，可降解 CCR2（DC50 为 2.6 μM）。还能够同时结合 CCR2 与 E3 连接酶 cereblon，呈现出持续且浓度依赖性的 CCR2 降解作用。LUF7996 依赖于溶酶体途径来诱导 CCR2 降解，并在体外有效抑制单核细胞的迁移。

化学信息

分子量	860.68
分子式	C₃₉H₃₄Cl₂F₃N₅O₈S
CAS No.	3104736-80-0
Smiles	O=C(NCCCCCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(OC5=CC=C(Cl)C=C5NS(=O)(=O)C6=CC=C(Cl)C(=C6)C(F)(F)F)C=C4

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

LUF7996