Name: Bempegaldesleukin
Brand: TargetMol
SKU: TP2549
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	Bempegaldesleukin (NKTR-214) is a PEGylated interleukin-2 (IL-2) that functions as an immunostimulatory IL-2 proagent, acting as a CD122-preferential agonist of the IL-2 pathway. It can stimulate an antitumor immune response [1].
体外活性	Bempegaldesleukin是一种IL-2前体药物，经过改造可提供受控、持续和优先的IL-2通路信号，目的是刺激抗肿瘤免疫反应，同时最大限度地降低毒性[1]。
体内活性	结合使用 Bempegaldesleukin (0.8 mg/kg；静脉注射7天) 和 NKTR-262 能以依赖 CD8+ T 细胞的方式显著提高两种肿瘤模型 (CT26 和 EMT6) 的存活率 [2]。
别名	NKTR-214, BEMPEG

化学信息

CAS No.	1939126-74-5
Sequence	{X}-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe (X= O-methylpolyethylene glycol (2 x 20 kDa mPEG)-Aib)
Sequence Short	{X}-SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF (X= O-methylpolyethylene glycol (2 x 20 kDa mPEG)-Aib)

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.

Bempegaldesleukin