Name: Olendalizumab
Brand: TargetMol
SKU: T77107
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 mg

待询

生物活性

产品描述	Olendalizumab (ALXN-1007) is a humanized monoclonal antibody specifically targeting the complement component C5a. The compound binds to C5a, blocking its interaction with the C5aR (CD88) receptor, thereby inhibiting C5a-mediated inflammatory responses, neutrophil chemotaxis, and activation. In clinical and experimental research, Olendalizumab is investigated for treating complement-mediated disorders, such as sepsis, graft-versus-host disease (GVHD), and severe pneumonia or cytokine storms induced by viral infections (e.g., COVID-19).
体外活性	在 Gyrolab 实验中，Olendalizumab 作为生物素化捕获试剂（在 Bioaffy wash 1 中的工作浓度为 100 µg/mL）表现出极高的特异性，配合 AlexaFluor 标记的抗 C5a 克隆 2942（在 Rexxip F 中浓度为 4 µg/mL），成功实现了对人血浆中游离 C5a 的精确定量检测 [1]。
体内活性	在病毒感染模型中，Olendalizumab 作为有效的 C5a 抑制剂，通过阻断由补体成分（C3、C5a、C5b-9）及其受体（C3aR、C5aR）介导的信号通路，显著减轻了肺部损伤，并特异性抑制了由冠状病毒诱导的“非沉默”补体激活过程 [2]。
别名	奥仑达利珠单抗, Lendalizumab, ALXN1007
反应种属	Virus
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
内毒素	<1.0 EU/mg

抗体信息

同型

IgG2SA

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P01031
靶点	ComplementproteinC5a

化学信息

CAS No.

2210314-30-8

储存&溶解度

存储	store at low temperature \| -20°C for 2 years, 4°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Olendalizumab