Name: Iluzanebart
Brand: TargetMol
SKU: T82077
Price: 2480 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,480

现货

5 mg

¥ 5,860

现货

10 mg

¥ 7,890

现货

25 mg

¥ 11,700

现货

50 mg

¥ 15,700

现货

生物活性

产品描述	Iluzanebart, a human monoclonal IgG1 antibody, functions as an agonist antibody for human TREM2 (hTREM2), thereby enhancing the survival and overall function of microglia through the activation of the TREM2 signaling pathway. Iluzanebart provides compensation for the loss of CSF1R function, and it can be employed as a research agent for adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP), thereby providing opportunities to model microglial dysfunction in neurodegenerative disorders.
体外活性	方法：Iluzanebart (10 µg/mL, 48-96 h)处理hMDM and iMGL细胞，使用 CellTiter Glo检测细胞活力。结果：Iluzanebart显著保护细胞免受PLX5622诱导的细胞活力下降。[1]
体内活性	方法：Iluzanebart (1-200 mg/kg, 单次) 腹腔注射给hTREM2-CV小鼠，通过RNA测序和细胞分析评估Iluzanebart对小胶质细胞基因表达和增殖的影响。结果：Iluzanebart增加了小鼠脑内小胶质细胞的增殖和CSF1R表面水平，特定趋化因子（如IP10和MIP1α）的水平也显著增加。[1]
别名	艾佐奈拜单抗
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
内毒素	<1.0 EU/mg

抗体信息

同型	Human IgG1 kappa
推荐同型对照	Human IgG1 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

储存&溶解度

存储	store at low temperature \| store at -20°C \| Shipping with blue ice/Shipping at ambient temperature.

Iluzanebart